426815-08-9Relevant academic research and scientific papers
The asymmetric synthesis of β-aryl-α-hydroxy esters from β-aryl-α,β-dihydroxy esters
Lawrence, Nicholas J,Brown, Stephen
, p. 613 - 619 (2002)
α,β-Dihydroxy-β-aryl esters obtained via Sharpless asymmetric dihydroxylation (AD) of substituted cinnamate esters are reduced by sequential reaction with trimethyl orthoacetate and acetyl bromide followed by catalytic hydrogenolysis in methanol to give enantiomerically enriched β-aryl-α-hydroxy esters.
Lipase-catalyzed transesterification as a practical route to homochiral syn-1,2-diols. The synthesis of the taxol side chain
Lee, Donghyun,Kim, Mahn-Joo
, p. 2163 - 2166 (2007/10/03)
syn-2,3-Dihydoxy-3-phenyl-propanoic acid methyl ester (1a) and its simple derivatives (1b-e) are efficiently resolved in LPS-catalyzed transesterification, leading to the synthesis of the taxol side chain and analogs from both resolved enantiomers.
