426825-49-2Relevant academic research and scientific papers
Syntheses of novel 4-tert-alkyl ether proline-based 16- and 17-membered macrocyclic compounds
Chen, Kevin X.,Njoroge, F. George,Vibulbhan, Bancha,Buevich, Alexei,Chan, Tze-Ming,Girijavallabhan, Viyyoor
, p. 2730 - 2733 (2007/10/03)
Starting from N-Cbz-4-hydroxyproline methyl ester 1, a boron trifluoride-diethyl etherate-catalyzed reaction provided 4-tert-alkyl ether proline 4. Two deprotections and amide bond formations furnished the phenol alcohol 2. The macrocyclization of 2 was accomplished through a Mitsunobu reaction using triphenylphosphine and 1,1′-(azodicarbonyl)dipiperidine (ADDP), to afford novel 16- and 17-membered proline-based macrocyclic compounds of type 3.
