426844-23-7

Basic information

• Product Name: 4-CIS-FLUORO-L-PROLINAMIDE HYDROCHLORIDE
• Synonyms: 4-CIS-FLUORO-L-PROLINAMIDE HYDROCHLORIDE;Cis-4-Fluoro-L-prolinamide hydrochloride;(2S,4S)-4-Fluoropyrrolidine-2-carboxaMide hydrochloride;(2S,4S)-4-Fluoropyrrolidine-2-carboxamide HCl;-4-Fluoropyrrolidine-2-carboxamide hydrochloride
• CAS NO: 426844-23-7
• Molecular Formula: C5H10ClFN2O
• Molecular Weight: 168.6
• Mol File: 426844-23-7.mol
• Article Data: 14

Chemical Properties

• Melting Point: 232°C
• Boiling Point: 337.3 °C at 760 mmHg
• Flash Point: 157.8 °C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 7.6E-05mmHg at 25°C
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: 4-CIS-FLUORO-L-PROLINAMIDE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CIS-FLUORO-L-PROLINAMIDE HYDROCHLORIDE(426844-23-7)
• EPA Substance Registry System: 4-CIS-FLUORO-L-PROLINAMIDE HYDROCHLORIDE(426844-23-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• Hazardous Substances Data: 426844-23-7(Hazardous Substances Data)

Usage

General Description

4-CIS-FLUORO-L-PROLINAMIDE HYDROCHLORIDE is a chemical compound with the molecular formula C5H8ClFN2O. It is a derivative of proline, a naturally occurring amino acid, and is used in pharmaceutical and chemical research. 4-CIS-FLUORO-L-PROLINAMIDE HYDROCHLORIDE is a white crystalline solid that is soluble in water and has potential applications in the development of therapeutic drugs. Its properties and structure make it a valuable building block in the synthesis of complex molecules, especially in the field of medicinal chemistry. Additionally, 4-CIS-FLUORO-L-PROLINAMIDE HYDROCHLORIDE has been studied for its potential antibacterial and antifungal properties, making it of interest for further investigation in the development of new pharmaceutical products.

InChI:InChI=1/C5H9FN2O.ClH/c6-3-1-4(5(7)9)8-2-3;/h3-4,8H,1-2H2,(H2,7,9);1H/t3-,4-;/m0./s1

Upstream product

• 203866-13-1 (2S,4S)-1-(tert-butoxycarbonyl)-4-fluoropyrrolidine-2-carboxylic acid 
• 203866-14-2 (2S,4R)-1-[(tert-butoxy)carbonyl]-4-fluoropyrrolidine-2-carboxylic acid 
• 426844-26-0 tert-butyl (2S,4R)-2-carbamoyl-4-fluoropyrrolidine-1-carboxylate 
• 426844-22-6 tert-butyl (2S,4S)-2-carbamoyl-4-fluoropyrrolidine-1-carboxylate 
• 88050-17-3 N-Fmoc-trans-4-Hydroxy-L-Proline 
• 1235447-40-1 (2S,4S)-N-Fmoc-4-fluoropyrrolidine-2-carbonyl fluoride 
• 1235447-46-7 (2S,4S)-N-Fmoc-4-fluoropyrrolidine-2-carboxamide 
• 748165-40-4 (2S,4S)-4-fluoropyrrolidine-2-carboxamide 

Downstream Products

• 596817-05-9 (2S,4S)-N-chloroacetyl-4-fluoropyrrolidine-2-carboxamide 
• 596817-06-0 (2S,4S)-1-(2-chloroacetyl)-4-fluoropyrrolidine-2-carbonitrile 

Relevant articles and documents

ETHER DERIVATIVES OF BICYCLIC HETEROARYLS

The invention relates to compounds of formula (I), wherein the substituents are as defined in the specification; to processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; such compounds as a medicament; such compounds for the treatment of a proliferative disease

NOVEL 4-FLUOROPYRROLIDINE-2-CARBONYL FLUORIDE COMPOUNDS AND THEIR PREPARATIVE METHODS

Novel 4-fluoropyrrolidine-2-carbonyl fluoride compounds as useful fluorinated intermediates are disclosed. Their preparative methods are also disclosed. Useful applications of the 4-fluoropyrrolidine-2-carbonyl fluorides are shown.

Synthesis and structure-activity relationships of potent 1-(2-substituted-aminoacetyl)-4-fluoro-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors

Dipeptidyl peptidase IV (DPP-IV) inhibitors have attracted attention as potential drugs for use in the treatment of type 2 diabetes because they prevent the degradation of glucagon-like peptide-1 (GLP-1) and extend its duration of action. We previously reported that 2-cyano-4-fluoropyrrolidines act as potent DPP-IV inhibitors and have been modifying the 1-position of pyrrolidine to obtain more useful inhibitors. An L-tert-butylglycine derivative was found to be a stable and potent DPP-IV inhibitor that exhibits a glucose lowering effect in vivo. Here, we report the synthesis of and biological data on the aforementioned derivatives.