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4269-94-7

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4269-94-7 Usage

General Description

6-Iodouracil is a chemical compound that is derived from uracil, a standard component of RNA. It is an iodine-substituted derivative of uracil, with the iodine atom replacing one of the hydrogen atoms on the carbon-6 position of the uracil ring. 6-Iodouracil is primarily used as a research tool in molecular biology and biochemistry for labeling and studying nucleic acids. It is also used in the synthesis of pharmaceuticals and as a precursor in the preparation of various organic compounds. The compound is known for its potential anti-tumor properties and is being investigated for its therapeutic applications in the treatment of cancer. Additionally, 6-Iodouracil may also have mutagenic and genotoxic effects, leading to its cautionary use in laboratory settings.

Check Digit Verification of cas no

The CAS Registry Mumber 4269-94-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,2,6 and 9 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 4269-94:
(6*4)+(5*2)+(4*6)+(3*9)+(2*9)+(1*4)=107
107 % 10 = 7
So 4269-94-7 is a valid CAS Registry Number.
InChI:InChI=1/C4H3IN2O2/c5-2-1-3(8)7-4(9)6-2/h1H,(H2,6,7,8,9)

4269-94-7Upstream product

4269-94-7Relevant articles and documents

Toward Fractioning of Isomers through Binding-Induced Acceleration of Azobenzene Switching

Vulcano, Rosaria,Pengo, Paolo,Velari, Simone,Wouters, Johan,De Vita, Alessandro,Tecilla, Paolo,Bonifazi, Davide

, p. 18271 - 18280 (2017)

The E/Z isomerization process of a uracil-azobenzene derivative in which the nucleobase is conjugated to a phenyldiazene tail is studied in view of its ability to form triply H-bonded complexes with a suitably complementary 2,6-diacetylamino-4-pyridine ligand. UV-vis and 1H NMR investigations of the photochemical and thermal isomerization kinetics show that the thermal Z E interconversion is 4-fold accelerated upon formation of the H-bonded complex. DFT calculations show that the formation of triple H-bonds triggers a significant elongation of the NN double bond, caused by an increase of its g? antibonding character. This results in a reduction of the NN torsional barrier and thus in accelerated thermal Z E isomerization. Combined with light-controlled E Z isomerization, this enables controllable fractional tuning of the two configurational isomers.

PROKINETICIN 1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF PAIN

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Page/Page column 43, (2012/01/13)

Disclosed are compounds, compositions and methods for treating pain, including inflammatory, visceral, and acute pain. Such compounds are represented by Formula (I) as follows: wherein A1, L1, D, and Q are defined herein.

PROKINETICIN 2 RECEPTOR ANTAGONISTS

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Page/Page column 115-116, (2010/11/28)

The present invention relates to certain novel compounds of Formula (I): and methods for the treatment of prokineticin 2 or prokinetin 2 receptor mediated disorders.

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