427-53-2 Usage
Uses
Used in Pharmaceutical Research and Drug Development:
4-fluoro-alpha-cyclopropyl-alpha-(4-fluorophenyl)-benzylic alcohol is utilized as a building block in the synthesis of various organic compounds, particularly those with potential pharmaceutical applications. Its unique structure may contribute to the development of new drugs with novel mechanisms of action.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-fluoro-alpha-cyclopropyl-alpha-(4-fluorophenyl)-benzylic alcohol is employed for its potential to enhance the properties of existing drugs or to create new therapeutic agents. Its fluorinated nature may impart specific characteristics that are beneficial for drug design, such as increased lipophilicity or altered metabolic stability.
Further Research:
While 4-fluoro-alpha-cyclopropyl-alpha-(4-fluorophenyl)-benzylic alcohol shows promise in pharmaceutical and medicinal applications, further research is necessary to fully understand its properties, potential uses, and any associated risks. This includes investigating its biological activity, pharmacokinetics, and potential side effects, as well as optimizing its synthesis and formulation for various applications.
Check Digit Verification of cas no
The CAS Registry Mumber 427-53-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,2 and 7 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 427-53:
(5*4)+(4*2)+(3*7)+(2*5)+(1*3)=62
62 % 10 = 2
So 427-53-2 is a valid CAS Registry Number.
InChI:InChI=1/C16H14F2O/c17-14-7-3-12(4-8-14)16(19,11-1-2-11)13-5-9-15(18)10-6-13/h3-11,19H,1-2H2
427-53-2Relevant academic research and scientific papers
Rapid access to halohydrofurans via bronsted acid-catalyzed hydroxylation/halocyclization of cyclopropyl methanols with water and electrophilic halides
Mothe, Srinivasa Reddy,Kothandaraman, Prasath,Rao, Weidong,Chan, Philip Wai Hong
experimental part, p. 2521 - 2531 (2011/05/14)
A one-pot, two-step method to prepare 3-halohydrofurans efficiently by TfOH-catalyzed hydroxylation/halocyclization of cyclopropyl methanols with H2O and N-halosuccinimide (NXS, X=1, Br, Cl) or Selectfluor is described. The reactions proceed rapidly under mild and operationally straightforward conditions with a catalyst loading as low as 1 mol % and afford the 3-halohydrofuran products in moderate to excellent yields and, in most cases, with preferential cis diastereoselectivity. The method was shown to be applicable to cyclopropyl methanols containing electron-withdrawing, electron-donating, and sterically demanding functional groups and electrophilic halide sources. The mechanism is suggested to involve protonation of the alcohol substrate by the Bronsted acid catalyst and ionization of the starting material. This results in ring-opening of the cyclopropane moiety and in situ formation of a homoallylic alcohol intermediate, which undergoes subsequent intramolecular halocyclization on treating with the electrophilic halide source to give the halohydrofuran. The observed cis product selectivity is thought to be determined by the reaction proceeding through an in situ generated unsaturated alcohol intermediate that contains a (Z)-alkene moiety under the kinetically controlled conditions.
