42710-52-1

Upstream product

• 15964-79-1 methyl (3,4-dimethoxyphenyl)acetate 
• 98-88-4 benzoyl chloride 
• 93-40-3 (3,4-Dimethoxyphenyl)acetic acid 

Downstream Products

• 41148-41-8 2,3-Methylbenzodiazepine-2 
• 41148-42-9 7,8-dimethoxy-1-phenyl-3,5-dihydro-4H-2,3-benzodiazepin-4-one 
• 132813-83-3 6,7-Dimethoxy-1-phenyl-2-benzopyran-3-one 
• 41148-49-6 2-benzoyl-4,5-dimethoxyphenylacetic acid 
• 89721-03-9 6,7-dimethoxy-1-phenyl-isoquinolin-3-ol 

Relevant academic research and scientific papers

New PDE4 inhibitors based on pharmacophoric similarity between papaverine and tofisopam

Pharmacophoric comparison between papaverine and tofisopam led to identify three new series of microto sub-micromolar inhibitors of phosphodiesterase-4, including 7,8-dialkoxy-2,3-benzodiazepin-4-one derivatives, 7,8-dialkoxy-1,4- benzodiazepin-2-one derivatives, and dialkoxybenzophenone derivatives.

Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof

The invention concerns novel benzodiazepine derivatives and their uses in the field of therapeutics particularly for treating pathologies involving the activity of a cyclic nucleotide phosphodiesterase. It also concerns methods for preparing them and novel synthesis intermediates. The inventive compounds more particularly correspond to general formula (I):

2-Benzopyran-3-ones Stabilised by Alkoxy Substituents

In contrast to the corresponding compounds lacking alkoxy substituents, the 2-benzopyran-3-ones 5, 6, 7 and 9 are stable and easily isolated.In contrast to the 6-methoxy derivative 7, the 7-methoxy isomer 8 cannot be isolated; the stabilising effect of th