42712-65-2

Upstream product

• 186581-53-3 diazomethane 
• 42712-64-1 2-amino-quinolin-4-ol 
• 53600-40-1 4-methoxy-2-quinaldamide 
• 14547-98-9 4-methoxyquinoline-N-oxide 
• 36726-69-9 2-cyano-4-methoxyquinoline 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 74-88-4 methyl iodide 

Downstream Products

• 42712-64-1 2-amino-quinolin-4-ol 
• 84357-09-5 (5-methoxy-imidazo[1,2-a]quinolin-2-yl)-phenyl-methanone 
• 84357-25-5 (5-Methoxy-imidazo[1,2-a]quinolin-2-yl)-p-tolyl-methanone 
• 84357-28-8 (4-Chloro-phenyl)-(5-methoxy-imidazo[1,2-a]quinolin-2-yl)-methanone 
• 84357-26-6 (5-Methoxy-imidazo[1,2-a]quinolin-2-yl)-(4-methoxy-phenyl)-methanone 

Relevant academic research and scientific papers

BENZOTHIOPHENE DERIVATIVE

[Problem to be Solved] It is intended to provide a compound having PDE10A inhibitory activity and having a novel structure, or an isotope thereof or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same as an active ingredient. [Solution] The present invention provides a compound represented by the general formula (I) or a pharmaceutically acceptable salt thereof.

Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells

The synthesis, biophysical and biological evaluation of a series of G-quadruplex interacting small molecules based on a N,N′-bis(quinolinyl) pyridine-2,6-dicarboxamide scaffold is described. The synthetic analogues were evaluated for their ability to stabilize telomeric G-quadruplex DNA, some of which showed very high stabilization potential associated with high selectivity over double-stranded DNA. The compounds exhibited growth arrest of cancer cells with detectable selectivity over normal cells. Long-time growth arrest was accompanied by senescence, where telomeric dysfunction is a predominant mechanism together with the accumulation of restricted DNA damage sites in the genome. Our data emphasize the potential of a senescence-mediated anticancer therapy through the use of G-quadruplex targeting small molecules based on the molecular framework of pyridostatin.