42718-20-7

Usage

Uses

Used in Pharmaceutical Synthesis:
METHYL 2-AMINO-2-(4-BROMOPHENYL)ACETATE HYDROCHLORIDE is used as a chemical intermediate for the synthesis of pharmaceuticals. Its unique structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Research Chemicals:
In the field of research, METHYL 2-AMINO-2-(4-BROMOPHENYL)ACETATE HYDROCHLORIDE is used as a research chemical. Its potential biological activity makes it valuable for studying various biological processes and mechanisms, contributing to the advancement of medical knowledge.
Used in Medicinal Chemistry:
METHYL 2-AMINO-2-(4-BROMOPHENYL)ACETATE HYDROCHLORIDE is utilized in medicinal chemistry for its potential applications in drug development. Its unique structure and properties make it a promising candidate for the design and synthesis of new therapeutic agents.
Used in Drug Development:
In the industry of drug development, METHYL 2-AMINO-2-(4-BROMOPHENYL)ACETATE HYDROCHLORIDE is used as a starting material or building block for the creation of new pharmaceutical compounds. Its potential biological activity and versatility in chemical synthesis make it an important tool in the development of innovative treatments for various diseases and conditions.

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 67-56-1 methanol 
• 119397-06-7 2-amino-2-(4-bromophenyl)acetic acid 

Downstream Products

• 1049837-69-5 methyl 2-(4-bromophenyl)-2-(2,3,4,5,6-pentafluorophenylsulfonamido)acetate 
• 1452588-95-2 methyl 2-isocyano-2-(4-bromophenyl)acetate 
• 1443792-42-4 methyl 2-(4-bromophenyl)-2-(5-(tert-butyl)thiophene-2-carboxamido)acetate 

Relevant academic research and scientific papers

Synthesis of 3-Hydroxymethyl Isoindolinones via Cobalt-Catalyzed C(sp2)-H Carbonylation of Phenylglycinol Derivatives

An efficient method for the synthesis of 3-hydroxymethyl isoindolinones via cobalt-catalyzed C(sp2)-H carbonylation of phenylglycinol derivatives using picolinamide as a traceless directing group is demonstrated. The reaction proceeds in the presence of a commercially available cobalt(II) tetramethylheptanedionate catalyst and employs DIAD as a "CO" surrogate. This synthetic route offers a broad substrate scope, excellent regioselectivity, and full preservation of the original stereochemistry. Besides, the developed method provides a pathway for accessing valuable enantiopure 3-substituted isoindolinone derivatives.

Cobalt-Catalyzed, Directed C-H Functionalization/Annulation of Phenylglycinol Derivatives with Alkynes

A new method for cobalt-catalyzed C(sp2)-H functionalization of phenylglycinol derivatives with terminal and internal alkynes directed by picolinamide auxiliary has been developed. This method offers an efficient and highly regioselective route for the synthesis of 1-hydroxymethyltetrahydroisoquinolines. The reaction employs commercially available Co(II) catalyst in the presence of Mn(III) cooxidant and oxygen as a terminal oxidant and proceeds with full preservation of original stereochemistry.

Triple role of phenylselenonyl group enabled a one-pot synthesis of 1,3-oxazinan-2-ones from α-isocyanoacetates, phenyl vinyl selenones, and water

Reaction of α-substituted α-isocyanoacetates with phenyl vinyl selenones in the presence of a catalytic amount of base (DBU or Et3N, 0.05-0.1 equiv) followed by addition of p-toluenesulfonic acid (PTSA, 0.1-0.2 equiv) afforded 4,4,5-trisubstituted 1,3-oxazinan-2-ones in good to excellent yields. Enantiomerically enriched heterocycles can also be prepared using a Cinchona alkaloid-derived bifunctional organocatalyst for the Michael addition step. The phenylselenonyl group served as an activator for the Michael addition, a leaving group and a latent oxidant in this integrated reaction sequence.

Efficient access to (1H)-isoindolin-1-one-3-carboxylic acid derivatives by orthopalladation and carbonylation of methyl arylglycinate substrates

The orthopalladation of methyl arylglycinate derivatives has been studied. The reaction proceeds efficiently for different electron-withdrawing and electron-releasing substituents at the aryl ring. The carbonylation of the orthopalladated complexes affords, in a single step, substituted (1H)-isoindolin-1-one-3-carboxylates. These compounds constitute valuable synthetic intermediates and can be transformed diastereoselectively into octahydroisoindole-1-carboxylic acid derivatives, an important scaffold in the synthesis of many biologically active compounds.