4272-07-5

Upstream product

• 22543-30-2 12-aminolauric acid hydrogen chloride salt 
• 501-53-1 benzyl chloroformate 
• 693-57-2 12-Aminododecanoic acid 
• 53005-24-6 methyl 12-aminododecanoate 
• 1129295-44-8 methyl 12-(benzyloxycarbonylamino)dodecanoate 

Downstream Products

• 4271-87-8 Benzyloxycarbonyl-bis-(12-amino-dodecansaeure)-methylester 
• 345287-87-8 (+)-1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-3-O-(4-methoxybenzyl)-sn-glycerol 
• 470665-52-2 methyl 2-[(12-benzyloxycarbonylamino)dodecanoyl]amino-2-deoxy-4,6-isopropylidene-3-O-tetradecanoyl-α-D-glucopyranoside 
• 1412439-58-7 tetrabenzyl 4,5-{1-O-[12-N-(benzyloxycarbonyl)aminododecanoyl]-2,3,6-tri-O-methoxymethyl-myo-inosityl}bisphosphate 
• 1412439-51-0 C₁₈H₃₇NO₁₃P₂ 
• 4271-88-9 Benzyloxycarbonyl-bis-(12-amino-dodecansaeure)-hydrazid 
• 470665-58-8 methyl 2-[(12-benzyloxycarbonylamino)dodecanoyl]amino-2-deoxy-6-O-mesyl-3-O-tetradecanoyl-α-D-glucopyranoside 
• 470665-64-6 methyl 6-amino-2-[(12-benzyloxycarbonylamino)dodecanoyl]amino-2,6-dideoxy-3-O-tetradecanoyl-α-D-glucopyranoside 
• 470665-61-3 methyl 6-azido-2-[(12-benzyloxycarbonylamino)dodecanoyl]amino-2,6-dideoxy-3-O-tetradecanoyl-α-D-glucopyranoside 
• 470665-55-5 methyl 2-[(12-benzyloxycarbonylamino)dodecanoyl]mino-2-deoxy-3-O-tetradecanoyl-α-D-glucopyranoside 

Relevant academic research and scientific papers

Molecular monolayer nanotubes having 7-9 nm inner diameters covered with different inner and outer surfaces

Novel unsymmetrical bolaamphiphile, bearing glucose- and triglycine-headgroups at both ends, exclusively self-assembled into nanotubes with 7-9-nm inner diameters, which consist of a single monolayer lined by polyglycine-II-type hydrogen-bond networks among the triglycine moieties. Copyright

PDE4 INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS

Provided herein are phosphodiesterase 4 (PDE4) inhibitors, e.g., a compound of Formula (I) or (II), and pharmaceutical compositions thereof. Also provided herein are methods of their use for treating, preventing, or ameliorating one or more symptoms of a disease, disorder, or condition associated with PDE4 malfunction.

COMPOUND OR SALT THEREOF, NATURAL KILLER T CELL ACTIVATOR, AND PHARMACEUTICAL COMPOSITION

The invention provides a compound or a salt thereof capable of activating natural killer T cell, a natural killer T cell activating agent containing such a compound or a salt thereof, and a pharmaceutical composition. The compound of the invention is a co

Versatile synthesis of 1-O-(Iω-aminolauryl)-I(4,5)P2

The synthesis of a model 1-O-(Iω-aminoacyl)-IP2 derivative, lauryl 4,5-bisphosphate 31, was realized following a versatile and high-yielding scheme. The flexible synthetic strategy used for this purpose allows the preparation of a range of othe

Supramolecular hydrogel formed by glucoheptonamide of l-lysine: simple preparation and excellent hydrogelation ability

We describe the simple preparation of new l-lysine derivatives with a gluconic or glucoheptonic group, their hydrogelation properties, and the thermal and mechanical properties of the supramolecular hydrogels. The l-lysine derivatives with a gluconic group have no hydrogelation ability, while the l-lysine-glucoheptonamide derivatives functioned as hydrogelators. Their hydrogelation abilities increased with the decreasing length of the spacer between the l-lysine segment and the glucoheptonic group. The compound, which has no spacer, formed a supramolecular hydrogel at 0.05 wt % in pure water. The thermal stability and high mechanical strength of the supramolecular hydrogels based on this compound significantly depended on the aqueous solutions. Electron microscopy and FTIR studies demonstrated?that the hydrogelators created a three-dimensional network through hydrogen bonding and hydrophobic interactions in the supramolecular hydrogel. In addition, it was found that hydrophobic interactions played an important role in the thermal stability of the supramolecular hydrogel.

Benzyl and tert-butyl carbamate derivatives of 1,ω-amino acids as simple yet efficient gelators

We report the synthesis and a study of the gelation properties of a series of N-protected long-chain amino acids. Especially, benzyl and tert-butyl carbamate derivatives of 11-aminoundecanoic acid in their deprotonated form can gelate polar organic solvents and water at very low concentration (less than 5 mM). This is explained by the contribution of multiple forces-H-bond, van der Waals and ionic interactions-in the gel aggregate formation and stabilization, which is confirmed by the experimental data. Among the series of compounds investigated, only a dimer of 11-aminoundecanoic acid is capable of gelating toluene, which stems from the increased number of hydrogen bonding sites in the main aliphatic chain.

PHOSPHOLIPID DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS

Disclosed are compounds having non-steroidal anti-inflammatory drugs (NSAIDS) covalently linked to a phospholipid moiety via a bridging group. Also disclosed are a process for the synthesis of the compounds, pharmaceutical compositions comprising the compounds and the use thereof for the treatment of diseases and disorders related to inflammatory conditions.