42754-63-2

Upstream product

• 58863-41-5 4-nitro-dithiobenzoic acid methyl ester 
• 5515-15-1 3-methoxy-3-(4-nitrophenyl)-2-cyanoacrylonitrile 
• 183739-67-5 3-(4-nitrophenyl)-3-methylmercapto-2-cyano-acrylonitrile 

Downstream Products

• 1092787-87-5 3-(4-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 183738-68-3 3-(4-tert-butoxycarbonylamino-phenyl)-4-(3-chloro-phenylamino)-1H-pyrazolo[3,4-d]pyrimidine 

Relevant academic research and scientific papers

FUSED RING HETEROARYL KINASE INHIBITORS

Provided herein are fused ring heteroaryl compounds useful in a variety of methods, including reducing the activity of certain kinases and treating certain disease states.

Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(Phenylamino)pyrazolo[3,4-d]pyrimidines

In the course of the random screening of a pool of CIBA chemicals, the two pyrazolopyrimidines 1 and 2 have been identified as fairly potent inhibitors of the EGF-R tyrosine kinase. Using a pharmacophore model for ATP- competitive inhibitors interacting w