5515-15-1Relevant articles and documents
3-PHENYL-5-UREIDOISOTHIAZOLE-4-CARBOXIMIDE AND 3-AMINO-5-PHENYLISOTHIAZOLE DERIVATIVES AS KINASE INHIBITORS
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, (2013/07/19)
This invention is directed to a compound of Formula I Formula I or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, n, X1, X2, L1, and L2 are as defined herein.
Pyrrole derivatives as potent inhibitors of lymphocyte-specific kinase: Structure, synthesis, and SAR
Takayama, Tetsuo,Umemiya, Hiroki,Amada, Hideaki,Yabuuchi, Tetsuya,Shiozawa, Fumiyasu,Katakai, Hironori,Takaoka, Akiko,Yamaguchi, Akie,Endo, Mayumi,Sato, Masakazu
scheme or table, p. 108 - 111 (2010/03/30)
We have described the synthesis, enzyme inhibitory activity, structure-activity relationships, and proposed binding mode of a novel series of pyrrole derivatives as lymphocyte-specific kinase (Lck) inhibitors. The most potent analogs exhibited good enzyme inhibitory activity (IC50s 10 nM) for Lck kinase inhibition.
CHEMICAL COMPOUNDS
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Page/Page column 39-40, (2008/06/13)
Pyrazole derivatives are described herein. The described invention also includes methods of making such pyrazole derivatives as well as methods of using the same in the treatment of diseases.