42754-64-3

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 27, p. 647, 1990 DOI: 10.1002/jhet.5570270332

Upstream product

• 42754-59-6 2-(1-Methoxy-2-phenylethylidene)malononitrile 
• 949-01-9 1-(morpholin-4-yl)-2-phenylethanethione 
• 476371-60-5 2-phenylacetylmalononitrile 
• 103-80-0 phenylacetyl chloride 
• 111509-98-9 3-Benzyl-2-cyano-3-morpholinoacrylonitrile 

Downstream Products

• 42754-71-2 4-Amino-3-benzylpyrazolo<3,4-d>pyrimidine 
• 129852-46-6 3-Benzyl-4,6-bis(methylthio)pyrazolo<3,4-d>pyrimidine 
• 476371-76-3 (2S,3R,4S,5R)-2-(4-amino-3-benzylpyrazolo[3,4-d]pyrimidin-1-yl)-5-hydroxymethyltetrahydrofuran-3,4-diol 
• 476371-80-9 C₁₇H₂₂N₅O₁₃P₃ 
• 476371-72-9 1-((2S,3R,4S,5R)-3,4-dibenzoyl-5-benzoylmethyltetrahydrofuran-2-yl)-3-benzyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine 

Relevant academic research and scientific papers

Inhibitor scaffolds as new allele specific kinase substrates

The elucidation of protein kinase signaling networks is challenging due to the large size of the protein kinase superfamily (>500 human kinases). Here we describe a new class of orthogonal triphosphate substrate analogues for the direct labeling of analog

Polarized Ethylenes. IV. Synthesis of Polarized Ethylenes Using Thioamides and Methyl Dithiocarboxylates and their Application to Syntheses of Pyrazoles, Pyrimidines, Pyrazolopyrimidines, and 5-Azacyclazines

Polarized ethylenes having both electron-donating (an amino or a methylthio group) and electron-accepting (cyano, carbamoyl, methyl ester) groups on the adjacent two olefinic carbon atoms were prepared by the condensation of S-alkylthioamidinium salts or

A NOVEL PREPARATION OF POLARIZED ETHYLENES BY THE REACTION OF THIOAMIDES OR DITHIOCARBOXYLATES WITH TETRACYANOETHYLENE OXIDE. SYNTHESIS OF PYRAZOLES AND PYRIMIDINES

Polarized ethylenes having both electron-donating (an amino or a methylthio group) and electron-accepting (two cyano groups) groups on the adjacent two olefinic carbon atoms were prepared by the reaction of thioamides or methyl dithiocarboxylates with tetracyanoethylene oxide in good yields.Reactions of these polarized ethylenes with hydrazine or guanidine carbonate gave the corresponding pyrazole and pyrimidine derivatives in good yields.