476371-60-5

Upstream product

• 103-80-0 phenylacetyl chloride 
• 109-77-3 malononitrile 
• 103-82-2 phenylacetic acid 

Downstream Products

• 186895-85-2 3-benzyl-1-tert-butyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 
• 42754-71-2 4-Amino-3-benzylpyrazolo<3,4-d>pyrimidine 
• 476371-72-9 1-((2S,3R,4S,5R)-3,4-dibenzoyl-5-benzoylmethyltetrahydrofuran-2-yl)-3-benzyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine 
• 476371-80-9 C₁₇H₂₂N₅O₁₃P₃ 
• 476371-76-3 (2S,3R,4S,5R)-2-(4-amino-3-benzylpyrazolo[3,4-d]pyrimidin-1-yl)-5-hydroxymethyltetrahydrofuran-3,4-diol 
• 42754-64-3 5-Amino-3-benzyl-1H-pyrazole-4-carbonitrile 

Relevant academic research and scientific papers

Inhibitor scaffolds as new allele specific kinase substrates

The elucidation of protein kinase signaling networks is challenging due to the large size of the protein kinase superfamily (>500 human kinases). Here we describe a new class of orthogonal triphosphate substrate analogues for the direct labeling of analog

Discovery of a potent protein kinase D inhibitor: insights in the binding mode of pyrazolo[3,4-d]pyrimidine analogues

In this study, we set out to rationally optimize PKD inhibitors based on the pyrazolo[3,4-d]pyrimidine scaffold. The lead compound for this study was 1-NM-PP1, which was previously found by us and others to inhibit PKD. In our screening we identified one compound (3-IN-PP1) displaying a 10-fold increase in potency over 1-NM-PP1, opening new possibilities for specific protein kinase inhibitors for kinases that show sensitivity towards pyrazolo[3,4-d]pyrimidine derived compounds. Interestingly the observed SAR was not in complete agreement with the commonly observed binding mode where the pyrazolo[3,4-d]pyrimidine compounds are bound in a similar fashion as PKD's natural ligand ATP. Therefore we suggest an alternate binding mode where the compounds are flipped 180 degrees. This possible alternate binding mode for pyrazolo[3,4-d]pyrimidine based compounds could pave the way for a new class of specific protein kinase inhibitors for kinases sensitive towards pyrazolo[3,4-d]pyrmidines.