42782-54-7

Usage

Uses

Used in Pharmaceutical Industry:
3-Chloro-4-ethylnitrobenzene is used as a key intermediate in the synthesis of glycine receptor antagonists, which are crucial for the treatment of neurological conditions such as ischemia and stroke. These antagonists help in modulating the overstimulation of glycine receptors, which can lead to neuronal damage and cell death in these conditions.

Upstream product

• 20191-74-6 2-ethyl-5-nitroaniline 
• 88975-09-1 2-(2-Chloro-4-nitro-phenyl)-2-methyl-malonic acid diethyl ester 
• 99-54-7 3,4-dichloronitrobenzene 
• 100-12-9 4-ethylnitrobenzene 

Downstream Products

• 50775-72-9 3-Chloro-4-ethylaniline 
• 67818-41-1 1-(2-chloro-4-nitrophenyl)ethanone 

Relevant academic research and scientific papers

Bis(dealkoxycarbonylation) of nitroarylmalonates: A facile entry to alkylated nitroaromatics

A simple approach to alkylated nitroaromatics from substituted nitroaryl malonic esters by double decarboxylation is detailed.

Alkyl, azido, alkoxy, and fluoro-substituted and fused quinoxalinediones

Methods of treating or preventing neuronal loss associated with stroke, ischemia, CNS trauma, hypoglycemia, and surgery, as well as treating neurodegenerative diseases including Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, and Down's syndrome, treating or preventing the adverse consequences of the hyperactivity of the excitatory amino acids, as well as treating anxiety, chronic pain, convulsions, and inducing anesthesia are disclosed by administering to an animal in need of such treatment an alkyl or azido-substituted 1,4-dihydroquinoxaline-2,3-dione or pharmaceutically acceptable salts thereof, which have high binding to the glycine receptor.