42785-81-9

Usage

Uses

Used in Pharmaceutical Research:
1-(2-METHYLBUT-3-YN-2-YL)-3-PHENYLUREA is used as a compound in pharmaceutical research for its potential unique biological activity, which may contribute to the development of new medications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-(2-METHYLBUT-3-YN-2-YL)-3-PHENYLUREA is used as a structural component for designing and synthesizing new molecules with therapeutic potential.
Used in Organic Synthesis:
1-(2-METHYLBUT-3-YN-2-YL)-3-PHENYLUREA is used as a building block in organic synthesis for creating more complex organic molecules with various applications.

Upstream product

• 2978-58-7 1,1-dimethylprop-3-ynylamine 
• 62-53-3 aniline 
• 103-71-9 phenyl isocyanate 

Downstream Products

• 92960-67-3 3,4,4-trimethyl-5-methylene-1-phenyl-imidazolidin-2-one 
• 42785-74-0 4,4-dimethyl-5-methylene-1-phenylimidazolidin-2-one 
• 1393746-07-0 C₃₀H₃₆F₂N₆O₁₀ 

Relevant academic research and scientific papers

Synthesis of Imidazolidin-2-ones and Imidazol-2-ones via Base-Catalyzed Intramolecular Hydroamidation of Propargylic Ureas under Ambient Conditions

The first organo-catalyzed synthesis of imidazolidin-2-ones and imidazol-2-ones via intramolecular hydroamidation of propargylic ureas is reported. The phosphazene base BEMP turned out to be the most active organo-catalyst compared with guanidine and amidine bases. Excellent chemo- and regioselectivities to five-membered cyclic ureas have been achieved under ambient conditions, with a wide substrate scope and exceptionally short reaction times (down to 1 min). A base-mediated isomerization step to an allenamide intermediate is the most feasible reaction pathway to give imidazol-2-ones, as suggested by DFT studies.

Metal-free 5-exo-dig cyclization of propargyl urea using TBAF

We present the first results of the intramolecular cyclization of propargyl ureas catalyzed by TBAF. Depending on the substituents close to the triple bond, imidazolone or methylene-imidazolidinone was obtained. The dual activation of the triple bond by interaction with TBAF via the cation-π is thought to be responsible.