427895-21-4Relevant articles and documents
Solid-phase synthesis of α-substituted 3-bisarylthio N-hydroxy propionamides as specific MMP Inhibitors
Chollet, Anne-Marie,Le Diguarher, Thierry,Kucharczyk, Nathalie,Loynel, Armelle,Bertrand, Marc,Tucker, Gordon,Guilbaud, Nicolas,Burbridge, Mike,Pastoureau, Philippe,Fradin, Armel,Sabatini, Massimo,Fauchère, Jean-Luc,Casara, Patrick
, p. 531 - 544 (2007/10/03)
A novel series of potent and specific MMP-2,3,9,13 inhibitors has been obtained by modulation on solid phase by α and aryl substitutions on 3-arylthio-N-hydroxy-propionamides starting from itaconic acid.