427899-56-7

Basic information

• Product Name: bis-di-tert-butyl methyl phosphate
• Synonyms: bis-di-tert-butyl methyl phosphate
• CAS NO: 427899-56-7
• Molecular Weight: 432.431
• Mol File: 427899-56-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: bis-di-tert-butyl methyl phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: bis-di-tert-butyl methyl phosphate(427899-56-7)
• EPA Substance Registry System: bis-di-tert-butyl methyl phosphate(427899-56-7)

Safety Data

• Hazardous Substances Data: 427899-56-7(Hazardous Substances Data)

Upstream product

• 593-71-5 Chloroiodomethane 
• 34075-24-6 tetramethylammonium di-tert-butyl hydrogen phsophate 
• 33494-80-3 potassium di-tert-butylphosphate 
• 117184-52-8 iodomethyl 4-methylbenzenesulfonate 
• 13086-84-5 di-tert-butyl phosphite 
• 33494-81-4 phosphoric acid di-tert-butyl ester 

Downstream Products

• 229625-50-7 di-tert-butyl chloromethyl phosphate 

Relevant articles and documents

Development of efficient processes for the preparation of Di-tert-butyl potassium phosphate and Di-tert-butyl (Chloromethyl) phosphate

A new and efficient process to prepare di-tert-butyl (chloromethyl) phosphate, a key compound in the formation of many phosphon-oxymethyl pro-drugs, from chloromethyl chlorosulfate (CMCS) and di-tert-butyl potassium phosphate (DTBPP) is described. To develop a process to this important compound with overall efficiency, an improved synthesis of DTBPP was required. The two-step process to DTBPP starts from PCl3 and leverages a H2O 2/catalytic KI mediated oxidation of di-tert-butyl phosphite to provide DTBPP in 81% yield and high purity. In the development of the new process to di-tert-butyl (chloromethyl) phosphate, a comparison to the corresponding tosylate derivative was made. A rational selection of base, phase-transfer catalyst (PTC), and stabilizing additive minimized CMCS decomposition and led to an optimized yield (90% solution yield), improved product purity, and identification of a technique to enable the long-term storage of di-tert-butyl (chloromethyl) phosphate.

WATER SOLUBLE PRODRUGS OF TERTIARY AMINE CONTAINING DRUGS AND METHODS OF MAKING THEREOF

The present invention is drawn to water soluble derivatives aliphatic acid aromatic secondary and tertiary amine containing drugs. The present invention is further drawn to methods of making water soluble derivatives of aliphatic and aromatic secondary and tertiary amine containing drugs.