42792-77-8

Upstream product

• 100-52-7 benzaldehyde 
• 98-53-3 4-tercbutyl-cyclohexanone 

Downstream Products

• 94990-49-5 6-tert-Butyl-4-phenyl-8-[1-phenyl-meth-(E)-ylidene]-3,4,5,6,7,8-hexahydro-quinazolin-2-ylamine 
• 141621-97-8 C₃₁H₃₂ 
• 94990-29-1 6-tert-Butyl-4-phenyl-8-[1-phenyl-meth-(E)-ylidene]-5,6,7,8-tetrahydro-quinazolin-2-ylamine 
• 94990-52-0 6-tert-Butyl-4-phenyl-8-[1-phenyl-meth-(E)-ylidene]-3,4,5,6,7,8-hexahydro-1H-quinazolin-2-ylideneamine; hydrochloride 
• 1263215-67-3 (E)-ethyl 7-benzylidene-9-tert-butyl-6-oxo-4-phenylspiro[4.5]dec-1-ene-1-carboxylate 
• 1263215-71-9 (E)-tert-butyl 7-benzylidene-9-tert-butyl-6-oxo-4-phenylspiro[4.5]dec-1-ene-1-carboxylate 

Relevant academic research and scientific papers

Nano titania-supported sulfonic acid catalyzed synthesis of α,α'-bis(substituted-benzylidene)cycloalkanones and of their xanthene derivatives under solvent-free conditions

An efficient, rapid and green synthesis of α,α'-bis(substituted-benzylidene)cycloalkanones and their xanthene derivatives is reported under solvent-free conditions using nano titania-supported sulfonic acid (n-TSA) as a reusable catalyst. This method offers many advantages, such as environmental friendliness reaction conditions, simplicity, short reaction times, easy work-up, reusability of catalyst, and high yields of products. Eight new compounds are reported too.

Organocatalytic enantioselective desymmetrization of cyclic enones via phosphine promoted [3+2] annulations

Phosphine catalyzed enantioselective [3+2] cyclizations on 4-substituted 2,6-diarylidenecyclohexanones and 2,4-diarylidene-bicyclo[3.1.0]hexan-3-ones take place with high diastereo- and enantioselectivity levels. The process affords spirocyclic compounds with excellent stereochemical control of up to five stereogenic centres.

Cytotoxic analogues of 2,6-bis(arylidene)cyclohexanones

A series of 2,6-bis(arylidene)cycloalkanones (1) and related compounds containing one or two substituents at the four position of the cyclohexyl ring were prepared and shown to display cytotoxic activity towards murine P388 and L1210 cells as well as human Molt 4/C8 and CEM T-lymphocytes. In some of the series of compounds, positive correlations were noted between the potencies of the enones and the magnitude of the Hammett σ values of the aryl substituents. Four representative compounds were cytotoxic to a number of human tumours in vitro, particularly towards colon cancer and leukemic cells. A noteworthy feature of the compounds prepared in this study is that, in general, they were well tolerated when administered to rodents. A number of lead molecules emerged from this investigation as well as guidelines for future expansion of these series of compounds.

Isomerization of crystalline 1,2,3-tris(arylmethylene)cyclohexanes to 1,2,3-tris(arylmethyl)benzenes by gaseous hydrogen bromide

1,2,3-Tris(arylmethylene)cyclohexanes (eleven examples) are prepared by aldol condensation from aromatic aldehydes and cyclohexanones, followed by Wittig olefination. They are rearranged nearly quantitatively by gasous hydrogen bromide to 1,2,3-tris(arylmethyl)benzenes.