42794-76-3 Usage
Uses
Antihypotensive.
Definition
ChEBI: An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydro
hloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.
Check Digit Verification of cas no
The CAS Registry Mumber 42794-76-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,7,9 and 4 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 42794-76:
(7*4)+(6*2)+(5*7)+(4*9)+(3*4)+(2*7)+(1*6)=143
143 % 10 = 3
So 42794-76-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)
42794-76-3Relevant articles and documents
Organobase-catalyzed amidation of esters with amino alcohols
Caldwell, Nicola,Jamieson, Craig,Simpson, Iain,Tuttle, Tell
supporting information, p. 2506 - 2509 (2013/06/27)
A base-mediated procedure for the amidation of unactivated esters with amino alcohols is reported. Optimization and exemplification of the catalytic process are described, furnishing products in 40-100% isolated yield.
A process for the preparation of midodrine
-
Example 3, (2010/01/31)
The invention provides a process for the preparation of 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide of the formula 1 by hydrogenolysis of substituted 2-dibenzylamino-N-[2-(2',5'-dimethoxyphenyl)-2-hydroxy-ethyl]acetamide having the formula (5), wherein Ar and Ar' are aryl groups.