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42794-76-3

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42794-76-3 Usage

Uses

Antihypotensive.

Definition

ChEBI: An aromatic ether that is 1,4-dimethoxybenzene which is substituted at position 2 by a 2-(glycylamino)-1-hydroxyethyl group. A direct-acting sympathomimetic with selective alpha-adrenergic agonist activity, it is used (generally as its hydro hloride salt) as a peripheral vasoconstrictor in the treatment of certain hypotensive states. The main active moiety is its major metabolite, deglymidodrine.

Check Digit Verification of cas no

The CAS Registry Mumber 42794-76-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,2,7,9 and 4 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 42794-76:
(7*4)+(6*2)+(5*7)+(4*9)+(3*4)+(2*7)+(1*6)=143
143 % 10 = 3
So 42794-76-3 is a valid CAS Registry Number.
InChI:InChI=1/C12H18N2O4/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16)

42794-76-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name midodrine

1.2 Other means of identification

Product number -
Other names 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)acetamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:42794-76-3 SDS

42794-76-3Downstream Products

42794-76-3Relevant articles and documents

Organobase-catalyzed amidation of esters with amino alcohols

Caldwell, Nicola,Jamieson, Craig,Simpson, Iain,Tuttle, Tell

supporting information, p. 2506 - 2509 (2013/06/27)

A base-mediated procedure for the amidation of unactivated esters with amino alcohols is reported. Optimization and exemplification of the catalytic process are described, furnishing products in 40-100% isolated yield.

A process for the preparation of midodrine

-

Example 3, (2010/01/31)

The invention provides a process for the preparation of 2-amino-N-[2-(2,5-dimethoxyphenyl)-2-hydroxyethyl]acetamide of the formula 1 by hydrogenolysis of substituted 2-dibenzylamino-N-[2-(2',5'-dimethoxyphenyl)-2-hydroxy-ethyl]acetamide having the formula (5), wherein Ar and Ar' are aryl groups.

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