42797-20-6

Basic information

• Product Name: 2-[(4-ethoxyphenyl)carbonyl]benzoic acid
• Synonyms: 2-[(4-ethoxyphenyl)carbonyl]benzoic acid;2-(4-ethoxybenzoyl)benzoic acid;2-[(4-ethoxyphenyl)-oxomethyl]benzoic acid;MFCD13379162
• CAS NO: 42797-20-6
• Molecular Formula: C₁₆H₁₄O₄
• Molecular Weight: 270.29
• Mol File: 42797-20-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[(4-ethoxyphenyl)carbonyl]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(4-ethoxyphenyl)carbonyl]benzoic acid(42797-20-6)
• EPA Substance Registry System: 2-[(4-ethoxyphenyl)carbonyl]benzoic acid(42797-20-6)

Safety Data

• Hazardous Substances Data: 42797-20-6(Hazardous Substances Data)

Usage

Derivative of benzoic acid

Yes

Physical form

White to off-white powder

Solubility

Insoluble in water, soluble in organic solvents

Uses

Intermediate in the synthesis of pharmaceuticals and agrochemicals, potential biological activities (anti-inflammatory, antibacterial), potential use as a chemical intermediate in the production of other organic compounds.

Upstream product

• 85-44-9 phthalic anhydride 
• 103-73-1 Phenetole 

Downstream Products

• 15987-90-3 9b-(4-ethoxy-phenyl)-1,2,3,9b-tetrahydro-imidazo[2,1-a]isoindol-5-one 
• 83257-71-0 1-oxo-2-phenyl-4-p-ethoxyphenyl-1,2-dihydrophthalazine 

Relevant articles and documents

Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 1. 2-[2-(1-imidazolyl)alkyl]- 1(2H)-phthalazinones

A number of 4-substituted 2-[ω-(1-imidazolyl)alkyl]-1(2H)-phthalazinones were synthesized in order to develop agents possessing both thromboxane A2 synthetase inhibitory and bronchodilatory activities. The pharmacological evaluation of these compounds disclosed that they have both activities to various extents. Both activities were slightly dependent on the length of the 2-substituents and largely affected by the nature of the 4-substituents. Compounds bearing phenyl and thienyl groups exhibited relatively high and well-rounded activities. Among these compounds, 12j and 15f were found to be the most effective agents having well-rounded activities in vitro and in vivo. Introduction of a carboxyl group reduced both activities contrary to our expectation. 4-(3-Pyridyl)phthalazinone 18b was of particular interest because of unexpectedly high in vivo activities in spite of an absence of significant in vitro activities.