4281-72-5Relevant academic research and scientific papers
Synthetic indole Mannich bases: Their ability to modulate in vitro cellular immunity
Mesaik, M. Ahmed,Khan, Khalid Mohammed,Rahim, Fazal,Taha, Muhammad,Haider, Syed Moazzam,Perveen, Shahnaz,Khalid, Ahmed Shukralla,Abdalla, Omer M.,Soomro, Samreen,Voelter, Wolfgang
, p. 118 - 122 (2015/06/02)
The synthetic indole Mannich bases 1-13 have been investigated for their ability to modulate immune responses measured in vitro. These activities were based on monitoring their affects on T-lymphocyte proliferation, reactive oxygen species (ROS), IL (inte
An efficient eco-friendly synthesis of Indole-Mannich base
Khan, Khalid Mohammed,Rahim, Fazal,Ambreen, Nida,Taha, Muhammad,Iqbal, Sarosh,Haider, Syed Moazzam,Perveen, Shahnaz
experimental part, p. 748 - 757 (2012/08/07)
An efficient and simplified protocol for three component Mannich reaction of indoles in water without using any catalyst is described. Different functionalized indole Mannich base synthesized in relatively short time with moderate to good yields. The adva
Design, synthesis, and biological evaluation of indole-based 1,4-disubstituted piperazines as cytotoxic agents
Akkoc, Meric Koeksal,Yueksel, Mine Yarim,Durmaz, Irem,Atalay, Renguel Ecetin
experimental part, p. 515 - 525 (2012/09/22)
A series of 3-[(4-substitutedpiperazin-1-yl)methyl]-1H -indole derivatives were synthesized, and their structures were confirmed by spectral analysis. All the compounds were tested for their cytotoxic activity in vitro against 3 human tumor cell lines: human liver (HUH7), breast (MCF7), and colon (HCT116). Among the designed derivatives, most of the compounds showed significant cytotoxicity against liver and colon cancer cell lines with lower IC50 concentrations than the standard drug 5-fluorouracil. Compound 3s, with 3,4-dichlorophenyl substituent on the piperazine ring, was the most active in suppressing the growth of all screened cancer cells. TUeBITAK.
Indole mannich bases and their antimycobacterial effect
Malinka, Wieslaw,Swiatek, Piotr
, p. 107 - 111 (2007/10/03)
3-[(4-arylpiperazin-1-yl)methyl]indoles (2a-h) and 3-[(4-hydroxy-4- phenylpiperazin-1-yl)methyl]indole (3) were prepared and characterized by 1H NMR and mass spectrometry. All eight compounds (2a-c, e-h and 3) tested inhibited in vitro the growth of Mycobacterium tuberculosis H 37Rv in the range of 98-7% at a concentration of ≥ 6.25 μg/ml. From the preliminary microbiological data it is possible to observe that a simple increasing of lipophilicity of the compounds tested to above logP calc. ≥3.8 significantly increases the potencies of their antitubercular action.
