42820-54-2Relevant academic research and scientific papers
A novel class of potential antidepressants: 1 aminoalkyl 1,3,4,9 tetrahydropyrano [3,4 b]indoles
Humber,Demerson,Asselin,et al.
, p. 215 - 220 (2007/10/05)
A series of twenty four 1,3,4,9 tetrahydropyrano[3,4 b]indoles bearing baic side chains at positions 1 or 9 have been synthesized and their acute toxicities and antidepressant properties have been determined. One of the most active compounds was 1,9 dimethyl 1 [2 (dimethylamino)ethyl] 1,3,4,9 tetrahydropyrano[3,4 b]indole hydrochloride (AY 23,671), having an ED50 of 0.51 mg/kg i.p. in mice in preventing reserpine induced ptosis. The enantiomers of this compound were examined and were found to have the same order of activity as the racemate.
