42823-46-1

Basic information

• Product Name: 4-Guanidinobenzoic acid hydrochloride
• Synonyms: 4-GUANIDOBENZOIC ACID HYDROCHLORIDE;4-GUANIDINOBENZOIC ACID HCL;4-GUANIDINOBENZOIC ACID HYDROCHLORIDE;TIMTEC-BB SBB003396;N-(4-CARBOXYPHENYL)GUANIDINE HYDROCHLORIDE;4-GUANIDINOBENZOIC ACID HCL CRYST;4-GUANIDINOBENZOIC ACID HYDROCHLORIDE, 9 9%;4-GUANIDINOBENZOIC ACID HYDROCHLORIDE 95+%
• CAS NO: 42823-46-1
• Molecular Formula: C₈H₉N₃O₂*ClH
• Molecular Weight: 215.64
• EINECS: 255-956-3
• Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Miscellaneous Reagents;Building Blocks;Chemical Synthesis;Guanidines;Nitrogen Compounds;Organic Building Blocks;nucleoside
• Mol File: 42823-46-1.mol
• Article Data: 7

Chemical Properties

• Melting Point: 285 °C (dec.)(lit.)
• Boiling Point: 438.4 °C at 760 mmHg
• Flash Point: 218.9 °C
• Appearance: Off-white solid
• Storage Temp.: 0-6°C
• Solubility: DMSO,(Slightly) Methanol (Slightly), Water (Slightly)
• Water Solubility: soluble
• BRN: 3718032
• CAS DataBase Reference: 4-Guanidinobenzoic acid hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Guanidinobenzoic acid hydrochloride(42823-46-1)
• EPA Substance Registry System: 4-Guanidinobenzoic acid hydrochloride(42823-46-1)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 42823-46-1(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 42823-46-1 differently. You can refer to the following data:
1. Aminobenzoic acid derivatives for treatment of chronic inflammatory diseases
2. 4-Guanidinobenzoic acid hydrochloride may be used in ELISA inhibition assay of mouse antiserum. It may be used in the synthesis of human acrosin inhibitor 4′-acetaminophenyl 4-guanidinobenzoate hydrochloride.2

General Description

4-Guanidinobenzoic acid hydrochloride is a guanidine derivative. Quality standard of 4-guanidinobenzoic acid hydrochloride has been investigated.

InChI:InChI=1S/C8H9N3O2.ClH/c9-8(10)11-6-3-1-5(2-4-6)7(12)13;/h1-4H,(H,12,13)(H4,9,10,11);1H

Upstream product

• 156-62-7 calcium cyanamide 
• 150-13-0 4-amino-benzoic acid 
• 1627898-15-0 2-[(4-cyanophenyl)amino]-4,6-dimethoxypyrimidine 
• 623-00-7 4-bromobenzenecarbonitrile 
• 420-04-2 CYANAMID 

Downstream Products

• 57438-34-3 p-Tolyl-4-guanidinobenzoat 
• 869363-13-3 4-{[9-chloro-7-(2,6-difluorophenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino}benzoic acid 
• 775263-30-4 ethyl 7-[(4-guanidinobenzoyl)amino]-1,2,3,4-tetrahydronaphthalene-2-acetate 
• 7035-79-2 4-guanidinobenzoyl chloride hydrochloride 
• 893554-62-6 C₁₈H₁₉N₅O₂ 
• 1315271-53-4 C₂₅H₃₈N₈O₅ 
• 1315271-58-9 C₄₅H₇₈N₈O₅ 
• 1315271-55-6 C₂₆H₄₀N₈O₅ 
• 1315271-54-5 C₂₆H₄₀N₈O₅ 
• 1204526-37-3 C₂₁H₁₇N₅O₄ 
• 1204526-31-7 4-[4-(2-methyl-7-morpholin-4-yl-imidazo[1,2-a]pyridin-3-yl)-pyrimidin-2-ylamino]-benzoic acid 
• 122228-09-5 N-(p-methoxycarbonylphenyl)guanidine 

Relevant articles and documents

Preparation method and application of Nafamostat mesylate intermediate

The invention belongs to the field of intermediate preparation and particularly relates to a preparation method and the application of a Nafamostat mesylate intermediate. The preparation method of theNafamostat mesylate intermediate comprises the step of enabling o/p-aminobenzoic acids to react with cyanamide under the action of a catalyst in a solvent, wherein the catalyst is hydrochloric acid ethanol or hydrochloric acid methanol and preferably selects the hydrochloric acid ethanol. The invention further provides a method for further preparing a Nafamostat mesylate impurity standard productby utilizing the method. With the adoption of the preparation method of the Nafamostat mesylate intermediate, the reaction time is shortened, the reaction yield is improved, and the production cost and the storage pressure are reduced. Therefore, implementation values and social economic benefits are greater. Moreover, impurities in the Nafamostat mesylate production are qualitatively and quantitatively analyzed by the impurity standard product, so that the quality standard of the product can be improved, and an important guiding significance is provided for safe medication.

Cleavage of 2-(Arylamino)-4,6-dimethoxypyrimidines to yield arylguanidines

A novel method for the synthesis of aryl-substituted guanidines in good overall yields is presented; it consists of the acidic cleavage of 2-(arylamino)-4,6-dimethoxypyrimidines, which were prepared by coupling aryl bromides with 2-amino-4,6-dimethoxypyrimidine. This methodology introduces a new means of protection for the guanidine functionality. Copyright

Methods and compositions for treating or preventing bacterial infection

The invention relates to compositions and methods for treating or preventing disease or disorders caused by or associated with certain bacterial infection, especially Escherichia coli (E. coli) or Helicobacter pylori (H. pylori) infection.