42832-64-4Relevant academic research and scientific papers
Benzophenone O-glucoside, a biogenic precursor of 1,3,7-trioxygenated xanthones in Hypericum annulatum
Kitanov, Gerassim M.,Nedialkov, Paraskev T.
, p. 1237 - 1243 (2001)
Two new benzophenones, hypericophenonoside (1) and annulatophenone (2) were isolated from the methanol extract of the herb of Hypericum annulatum. The structures of the benzophenones were established as 2′-O-β-D-glucopyranosyl-2,4,5′,6-tetrahydroxybenzophenone (1) and 2,3′,5′,6-tetrahydroxy-4-methoxybenzophenone (2) based on spectral and chemical evidence. Hypericophenonoside is the second benzophenone O-glycoside found in nature. Acid and enzymatic hydrolysis of (1) has led directly to the formation of 1,3,7-trihydroxyxanthone (gentisein). This fact confirmed the hypothesis that some xanthones could be formed in plants by dehydration of 2,2′-dihydroxybenzophenones, and the intermediate precursors appear to be benzophenone O-glycosides ortho to the carbonyl function.
Arylalkyl ketones, benzophenones, desoxybenzoins and chalcones inhibit TNF-α induced expression of ICAM-1: Structure-activity analysis
Kumar, Sarvesh,Reddy L, Chandra Shekhar,Kumar, Yogesh,Kumar, Amit,Singh, Brajendra K.,Kumar, Vineet,Malhotra, Shashwat,Pandey, Mukesh K.,Jain, Rajni,Thimmulappa, Rajesh,Sharma, Sunil K.,Prasad, Ashok K.,Biswal, Shyam,Van Der Eycken, Erik,Depass, Anthony L.,Malhotra, Sanjay V.,Ghosh, Balaram,Parmar, Virinder S.
experimental part, p. 368 - 377 (2012/07/31)
The interaction between leukocytes and the vascular endothelial cells (EC) via cellular adhesion molecules plays an important role in the pathogenesis of various inflammatory and autoimmune diseases. Small molecules that block these interactions have been targeted as potential therapeutic agents against acute and chronic inflammatory diseases. In an effort to identify potent intercellular cell adhesion molecule-1 (ICAM-1) inhibitors, a large number of arylalkyl ketones, benzophenones, desoxybenzoins and chalcones and their analogs (54 in total) have been synthesized and screened for their ICAM-1 inhibitory activity. The structure-activity relationship studies of these compounds identified three potent chalcone derivatives and also demonstrated the possible mechanism for their ICAM-1 inhibitory activities. The most active compound was found to be 79. A large number of arylalkyl ketones, benzophenones, desoxybenzoins and chalcones as well as their analogs (54 in total) were synthesized and screened for their ICAM-1 inhibitory activity. The structure-activity relationship studies of these compounds identified three potent chalcone derivatives and also demonstrated a possible mechanism of their ICAM-1 inhibitory activities. The most active compound was found to be 79. Copyright
