428453-40-1

Upstream product

• 35840-83-6 (Z)-5-Phenyl-4-penten-1-amine 
• 98-59-9 p-toluenesulfonyl chloride 
• 13159-16-5 (E)-5-phenyl-4-penten-1-ol 
• 70-55-3 toluene-4-sulfonamide 
• 13159-16-5 (Z)-5-phenylpent-4-en-1-ol 
• 160257-00-1 (Z)-(5-bromopent-1-en-1-yl)benzene 
• 374094-69-6 (Z)-(5-chloropent-1-en-1-yl)benzene 
• 536-74-3 phenylacetylene 
• 24463-87-4 (5-chloropent-1-ynyl)benzene 
• 1123202-95-8 (Z)-(5-iodopent-1-en-1-yl)benzene 
• 99858-43-2 5-phenylpent-4-enylamine 
• 7743-29-5 [3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propyl]-triphenyl-phosphonium bromide 
• 24595-58-2 5-phenylpent-4-yn-1-ol 
• 110-87-2 3,4-dihydro-2H-pyran 

Downstream Products

• 1180843-90-6 C₂₀H₂₃NO₂S 
• 1613582-73-2 C₂₄H₂₅NO₂S₂ 
• 1613582-61-8 (2R,3R)-N-(4-toluenesulfonyl)-2-phenyl-3-(phenylthio)piperidine 

Relevant academic research and scientific papers

Oxidative hydroxylation mediated by alkoxysulfonium ions

Oxidative hydroxylation of toluene derivatives via alkoxysulfonium ion intermediates was achieved by integration of anodic oxidation and hydrolysis to give benzyl alcohols which are also susceptible to oxidation. Alkenes were also oxidized to give 1,2-diols without overoxidation. The integration of electrochemical oxidative cyclization and hydrolysis was achieved using alkenes bearing a nitrogen atom in an appropriate position to give cyclic β-amino-substituted alcohols.

Enamide-benzyne-[2 + 2] cycloaddition: Stereoselective tandem [2 + 2]-pericyclic ring-opening-intramolecular N-tethered [4 + 2] cycloadditions

Image Presented Benzyne-[2 + 2] cycloadditions with enamides are described. This effort led to the development of a highly stereoselective tandem [2 + 2] cycloaddition-pericyclic ring-opening-intramolecular-N-tethered-[4 + 2] cycloaddition for rapid assembly of nitrogen heterocycles.

Two-faced reactivity of alkenes: cis- versus trans-aminopalladation in aerobic Pd-catalyzed intramolecular Aza-Wacker reactions

A number of different PdII catalyst systems have been reported recently for the Wacker-type aerobic oxidative cyclization of alkenes bearing tethered nitrogen nucleophiles. This study examines the stereochemistry of the aminopalladation step wi

Bronsted acid-catalyzed intramolecular hydroamination of protected alkenylamines. Synthesis of pyrrolidines and piperidines.

[reaction: see text]. The cyclization of aminoalkenes bearing an electron-withdrawing group on the nitrogen atom was catalyzed by triflic or sulfuric acid in toluene. Pyrrolidines and piperidines were formed in excellent yields. N-phenylanilides also underwent cyclization to form gamma-lactams.