24463-87-4

Usage

Uses

Used in Pharmaceutical Industry:
(5-chloropent-1-yn-1-yl)benzene is used as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving the efficacy of existing ones.
Used in Dye Industry:
In the dye industry, (5-chloropent-1-yn-1-yl)benzene is utilized as a precursor for the production of various dyes, enhancing the color properties and performance of these dyes in different applications.
Used in Agrochemical Industry:
(5-chloropent-1-yn-1-yl)benzene serves as an essential component in the formulation of agrochemicals, such as pesticides and herbicides, helping to improve crop protection and yield.
Used as a Solvent in Coatings Industry:
In the coatings industry, (5-chloropent-1-yn-1-yl)benzene is employed as a solvent for resins, paints, and varnishes, providing improved solubility and performance characteristics for these products.
Used in Organic Synthesis:
(5-chloropent-1-yn-1-yl)benzene is used as a versatile intermediate in the synthesis of a wide range of organic compounds, enabling the development of new chemical entities and enhancing the properties of existing ones.
Safety Considerations:
Due to its flammability and potential health hazards, it is crucial to follow proper handling and storage procedures when working with (5-chloropent-1-yn-1-yl)benzene to ensure the safety of personnel and the environment.

Upstream product

• 57718-13-5 (5-bromo-pent-1-ynyl)-benzene 
• 124-63-0 methanesulfonyl chloride 
• 591-50-4 iodobenzene 
• 14267-92-6 1-chloro-4-pentyne 
• 6738-06-3 phenylethynylmagnesium bromide 
• 6940-76-7 1-iodo-3-chloro-propane 
• 65-85-0 benzoic acid 
• 545-06-2 trichloroacetonitrile 
• 56-23-5 tetrachloromethane 
• 317374-16-6 dimethyl(5-chloropent-1-ynyl)silanol 
• 1004-22-4 (phenylethynyl)sodium 
• 109-70-6 1.3-chlorobromopropane 
• 4440-01-1 lithium phenylacetylide 
• 536-74-3 phenylacetylene 

Downstream Products

• 110-94-1 1,5-pentanedioic acid 
• 65-85-0 benzoic acid 
• 77213-81-1 2-(5-Phenyl-pent-4-ynyl)-isothiourea; hydrochloride 
• 147597-80-6 methyl 2-carbomethoxy-7-phenyl-6-heptynoate 
• 467249-01-0 2-bromo-1-(5-phenylpent-4-ynyl)-1H-indole-3-carboxaldehyde 
• 568571-30-2 methyl 2-iodo-1-(5-phenylpent-4-ynyl)-1H-indole-3-carboxylate 
• 72709-30-9 N-phenyl-2-phenylpiperidine 
• 244016-01-1 trans-N-phenyl-5-phenyl-4-penten-1-amine 
• 244015-98-3 trans-N-phenyl-N-methyl-5-phenyl-4-penten-1-amine 
• 29313-49-3 5-phenylpent-4-yn-1-yl acetate 
• 24595-58-2 5-phenylpent-4-yn-1-ol 
• 1610681-62-3 1-[3-(3-chloropropyl)-2-phenylindol-1-yl]ethanone 
• 1610681-63-4 1-[2-(3-chloropropyl)-3-phenylindol-1-yl]ethanone 
• 1638178-42-3 4-(3-chloropropyl)-1,1-dimethyl-3-phenyl-1H-isochromene 

Relevant academic research and scientific papers

Ru-catalysed C(sp2)-H vinylation/annulation of benzoic acids and alkynes: rapid access to medium-sized lactones

An unprecedented ruthenium catalysed [4+4] annulation of readily available benzoic acids and alkynes is reported for the first time. The carboxylate group acts as both a directing group and an internal nucleophilic reagent to facilitate a C(sp2

(: Z)-Tetrahydrothiophene and (Z)-tetrahydrothiopyran synthesis through nucleophilic substitution and intramolecular cycloaddition of alkynyl halides and EtOCS2K

This protocol provides a novel, environmentally friendly and simple method for the synthesis of (Z)-tetrahydrothiophene derivatives using the nucleophilic thiyl radical intramolecular cycloaddition cascade process to construct C-S bonds under transition-m

Interrupted Carbonyl-Alkyne Metathesis

Carbonyl-olefin metathesis and carbonyl-alkyne metathesis represent established reactivity modes between carbonyls, alkenes, and alkynes under Lewis and Br?nsted acid catalysis. Recently, an interrupted carbonyl-olefin metathesis reaction has been reporte

An imidazole-functionalized polyacetylene: Convenient synthesis and selective chemosensor for metal ions and cyanide

A new light-emitting polyacetylene bearing imidazole moieties in the side chain (P1), was conveniently prepared through a postfunctionalization strategy, as a sensory polymer to selectively report the presence of Cu2+ (with a detection limit of

Organocobaloxime in organic synthesis: efficient trapping of 5-phenylpent-4-ynyl radical by useful functional groups

5-Phenylpent-4-ynyl cobaloxime, R(CoIII) reacts with the free radical precursors XY under thermal or photochemical conditions to give the corresponding organic product RX or RY, depending on the precursor.A non-chain radical mechanism is invoked to account for the product distribution. Key words: Cobaloxime; Radical

Decarbonylative Sonogashira Cross-Coupling of Carboxylic Acids

Decarbonylative Sonogashira cross-coupling of carboxylic acids by palladium catalysis is presented. The carboxylic acid is activated in situ by the formation of a mixed anhydride and further decarbonylates using the Pd(OAc)2/Xantphos system to provide an aryl-Pd intermediate, which is intercepted by alkynes to access the traditional Pd(0)/(II) cycle using carboxylic acids as ubiquitous and orthogonal electrophilic cross-coupling partners. The methodology efficiently constructs new C(sp2)-C(sp) bonds and can be applied to the derivatization of pharmaceuticals. Mechanistic studies give support to decarbonylation preceding transmetalation in this process.

SYNTHESIS OF CAPSAICIN DERIVATIVES

The present invention relates to the synthesis of capsaicin derivatives, specifically to the synthesis of 6-heptyne derivatives of capsaicin.

Sonogashira Cross-Coupling of Aryltrimethylammonium Salts

A protocol for C(sp)-C(sp2) bond formation via the Sonogashira coupling reaction involving C-N bond cleavage with aryltrimethylammonium triflate as an electrophilic coupling partner is described in this work. The reactions proceeded well under mild conditions with a stoichiometric ratio of alkyl, aryl, or heteroaryl acetylenes and provided yields of up to 93%. Numerous useful functional groups were tolerated under the reaction conditions. Direct amine alkynylation can be achieved through a one-pot process without the isolation of ammonium salt. The protocol can be performed on a gram scale. Density functional theory calculations were performed to investigate the reaction mechanism that involved oxidative addition, alkyne coordination, deprotonation, and reductive elimination, which yielded the cross-coupling product.

A Commercially Available and User-Friendly Catalyst for Hydroamination Reactions under Technical Conditions

The activity of a simple, commercially available copper salt, [Cu(NCMe)4](BF4) in intramolecular hydroamination reactions of alkynes and allenes is presented. Reactions were successfully carried out in technical acetonitrile in the presence of air. While attempts of alkene hydroamination failed, this catalyst was also found active in intermolecular aza-Michael reactions.

Palladium(II) complex for catalyzing sonogashira coupling reactions and a method thereof

A palladium(II) complex which catalyzes the Sonogashira coupling reaction efficiently under aerobic condition and a method of employing the palladium(II) complex to synthesize internal alkynes. The palladium(II) complex is an effective catalyst for the co