428468-34-2

Basic information

• Product Name: 4-[(4-ForMylphenoxy)Methyl]benzoic acid
• Synonyms: 4-[(4-ForMylphenoxy)Methyl]benzoic acid
• CAS NO: 428468-34-2
• Molecular Formula: C₁₅H₁₂O₄
• Molecular Weight: 256.25338
• Mol File: 428468-34-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[(4-ForMylphenoxy)Methyl]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4-ForMylphenoxy)Methyl]benzoic acid(428468-34-2)
• EPA Substance Registry System: 4-[(4-ForMylphenoxy)Methyl]benzoic acid(428468-34-2)

Safety Data

• Hazardous Substances Data: 428468-34-2(Hazardous Substances Data)

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 108052-76-2 4-(bromomethyl)benzoic acid 1,1-dimethylethyl ester 
• 6232-88-8 4-bromomethylbenzoic Acid 

Relevant articles and documents

Accurate sequence stimuli-responsive polymer as well as preparation method and application thereof

The invention provides an accurate sequence stimuli-responsive polymer as well as a preparation method and application thereof. The polymer has a structure shown in a formula I in the specification. The polymer induces a trigger element to break under corresponding stimulation conditions, and then spontaneous sequential depolymerization is carried out through electron rearrangement. Compared with most stimulus-responsive polymers researched at present, the polymer has the advantages that the number of repeated units is determined, the sequence is controllable, and the preparation method is efficient in reaction, short in reaction time and high in yield. According to the characteristics of the accurate polymer, the polymer is expected to be used in the application fields of signal amplification, degradable nano materials, sensing application devices, drug delivery, controllable release and the like.

Identification of para-Substituted Benzoic Acid Derivatives as Potent Inhibitors of the Protein Phosphatase Slingshot

Slingshot proteins form a small group of dual-specific phosphatases that modulate cytoskeleton dynamics through dephosphorylation of cofilin and Lim kinases (LIMK). Small chemical compounds with Slingshot-inhibiting activities have therapeutic potential against cancers or infectious diseases. However, only a few Slingshot inhibitors have been investigated and reported, and their cellular activities have not been examined. In this study, we identified two rhodanine-scaffold-based para-substituted benzoic acid derivatives as competitive Slingshot inhibitors. The top compound, (Z)-4-((4-((4-oxo-2-thioxo-3-(o-tolyl)thiazolidin-5-ylidene)methyl)phenoxy)methyl)benzoic acid (D3) had an inhibition constant (Ki) of around 4 μm and displayed selectivity over a panel of other phosphatases. Moreover, compound D3 inhibited cell migration and cofilin dephosphorylation after nerve growth factor (NGF) or angiotensin II stimulation. Therefore, our newly identified Slingshot inhibitors provide a starting point for developing Slingshot-targeted therapies.