108052-76-2

Usage

Uses

Used in Organic Chemistry:
4-(Bromomethyl)-benzoic acid, 1,1-dimethylethyl ester is used as a reagent for various chemical reactions, facilitating the synthesis of a range of organic compounds. Its unique structure, featuring a bromomethyl and a 1,1-dimethylethyl ester group, makes it a valuable component in the creation of new molecules with specific properties and applications.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 4-(Bromomethyl)-benzoic acid, 1,1-dimethylethyl ester is used as an intermediate in the development of new drugs. Its ability to participate in various chemical reactions allows for the creation of diverse drug candidates with potential therapeutic benefits.
Used in Chemical Research:
4-(Bromomethyl)-benzoic acid, 1,1-dimethylethyl ester is also employed in chemical research as a model compound to study the properties and reactivity of esters and bromomethyl groups. This helps researchers gain insights into the behavior of similar compounds and develop new synthetic strategies and applications.
Used in Material Science:
In the field of material science, 4-(Bromomethyl)-benzoic acid, 1,1-dimethylethyl ester is utilized in the synthesis of novel materials with specific properties, such as polymers, coatings, and adhesives. Its versatility in chemical reactions enables the development of materials with tailored characteristics for various applications.
Overall, 4-(Bromomethyl)-benzoic acid, 1,1-dimethylethyl ester is a versatile chemical compound with a wide range of applications in different industries, including organic chemistry, pharmaceuticals, chemical research, and material science. Its unique structure and reactivity make it an essential component in the synthesis of various organic compounds and the development of new materials and drugs. However, due to its potential health and safety risks, it is crucial to handle 4-(BROMOMETHYL)-BENZOIC ACID, 1,1-DIMETHYLETHYL ESTER with care and follow appropriate safety protocols.

InChI:InChI=1/C12H15BrO2/c1-12(2,3)15-11(14)10-6-4-9(8-13)5-7-10/h4-7H,8H2,1-3H3

Upstream product

• 13756-42-8 tert-butyl 4-methylbenzoate 
• 6232-88-8 4-bromomethylbenzoic Acid 
• 115-11-7 isobutene 
• 52780-16-2 4-bromomethylbenzoyl chloride 
• 865-47-4 potassium tert-butylate 
• 99-94-5 p-Toluic acid 
• 98946-18-0 tert-Butyl 2,2,2-trichloroacetimidate 
• 4885-02-3 Dichloromethyl methyl ether 
• 75-65-0 tert-butyl alcohol 
• 128-08-5 N-Bromosuccinimide 
• 71432-55-8 2-tert-butyl-1,3-diisopropylisourea 
• 874-60-2 4-methyl-benzoyl chloride 
• 540-88-5 acetic acid tert-butyl ester 
• 15679-00-2 tert-butyl 2,2,2-trichloroacetimidate 

Downstream Products

• 126062-58-6 dimethyl<4-(tert-butoxycarbonyl)benzyl><(trimethylsilyl)methyl>ammonium bromide 
• 156143-60-1 4-[2-(Benzhydrylidene-amino)-2-ethoxycarbonyl-ethyl]-benzoic acid tert-butyl ester 
• 127153-49-5 (+/-)-4-<(1,1-dimethylethoxy)carbonyl>-α-<(diphenylmethylene)amino>benzenepropanoic acid phenylmethyl ester 
• 1064666-73-4 4-(2-(Dimethyl-hydrazonomethyl)-6-{4-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-phenyl}-hexyl)-benzoic acid tert-butyl ester 
• 1064666-75-6 4-(2-(Dimethyl-hydrazonomethyl)-7-{4-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-phenyl}-heptyl)-benzoic acid tert-butyl ester 
• 118507-44-1 t-butyl 4-fluoromethylbenzoate 
• 118537-46-5 {[4-(t-butoxycarbonyl)phenyl]methyl}triphenylphosphonium bromide 
• 118537-46-5 <4-(tert-Butyloxycarbonyl)benzyl>triphenylphosphonium Bromide 
• 246539-85-5 (3S,5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-methyl-3-[4'-(tert-butyloxycarbonyl)benzyl]-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one 
• 273935-08-3 allyl 2,3,4-tri-O-benzyl-6-O-[4-(tert-butoxycarbonyl)benzyl]-α-D-glucopyranoside 

Relevant academic research and scientific papers

Investigation of the Stereoselective Synthesis of the Indane Dimer PH46A, a New Potential Anti-inflammatory Agent

PH46A, belonging to a class of 1,2-Indane dimers, has been developed by our research group as a potential therapeutic agent for the treatment of inflammatory and autoimmune diseases. The initial synthetic route to PH46A gave a low overall yield, due in la

Design, synthesis and structure?activity relationship studies of GPR40 agonists containing amide linker

Free fatty acid receptor 1 (FFAR1/GPR40) attracted significant attention as a potential target for developing novel antidiabetic drugs because of its unique mechanism in glucose homeostasis. Several reports have expressed concerns about central nervous system (CNS) penetration of GPR40 agonists, which is possibly attributed to their high lipophilicity and low total polar surface area. Herein, we report our efforts to improve the physicochemical properties and pharmacokinetic profiles of LY2881835, a GPR40 agonist that had undergone Phase I clinical trial, through a series of structural optimizations. We identified an orally efficacious compound, 15k, which possessed increased plasma exposure, prolonged half-life and reduced CNS exposure and liver to plasma distribution ratio compared with LY2881835. 15k is a potentially valuable lead compound in the development of safe and efficacious GPR40-targeted drugs to treat type 2 diabetes mellitus.

Novel nicotinoid structures for covalent modification of wood: An environmentally friendly way for its protection against insects

Timber is constantly exposed to environmental influences under outdoor conditions which limits its lifetime and usability. In order to counteract the damaging processes caused by insects, we have developed a novel and more environmentally friendly method to protect wood materials via covalent modification by organic insecticides. Starting with an important class of synthetic insecticides which are derived from the natural insecticide nicotine, various new carboxylic acid derivatives of imidacloprid were made accessible. These activated neonicotinoids were utilized for the chemical modification of wood hydroxy groups. In contrast to conventional wood preservation methods in which biocides are only physically bound to the surface for a limited time, the covalent fixation of the preservative guarantees a permanent effect against wood pests, demonstrated in standardized biological tests. Additionally, the environmental interaction caused by non-bound neonicotinoids is significantly reduced, since both, a smaller application rate is required and leaching of the active ingredient is prevented. By minimizing the pest infestation, the lifetime of the material increases while preserving the natural appearance of the material.

Acid-Stable Ester Linkers for the Solid-Phase Synthesis of Immobilized Peptides

A series of N-terminally Fmoc-protected linkers of the general formula Fmoc-X?CO?O?Y?COOH have been prepared, where X is ?NH?CH2?CH2- or -p-(aminomethyl)phenyl- and Y is ?(CH2)n? (n is 1 or 4) or -p-(methyl)phenyl-. These linkers can easily be covalently attached via their C-terminal carboxyl group to a resin bearing a free amino group. After cleavage of the N-terminal Fmoc group, the linkers can be extended by standard solid-phase peptide synthesis techniques. These ester linkers are acid-stable and resistant to the base-mediated diketopiperazine formation that often occurs during the synthesis of ester-bound peptides; they are stable at neutral pH in aqueous buffers for days but can be effectively cleaved with 0.1 m NaOH or aq. ammonia within minutes or hours, respectively. These properties make these ester handles well suited for use as linkers for the solid-phase peptide synthesis of immobilized peptides when the stable on-resin immobilization of the peptides and the testing of their biological properties in aqueous buffers at neutral pH are necessary.

3-(1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE DERIVATIVES AND USES THEREOF

The present disclosure provides a compound of Formula (I′): or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, or tautomer thereof, wherein R1, R2, Rx, X1, n, n1, and q are as defined herein, and methods of making and using same.

A class of GPR40 agonist compounds with amide structure, and uses thereof

The present invention relates to a class of amide compounds with a novel structure, and a pharmaceutical composition thereof, wherein the structure of the amide compound is represented by a general formula (I). According to the present invention, the amide compound (I) can regulate GPR40 activity, and can be used for GPR40 activity related diseases such as diabetes and metabolic syndrome. The formula I is defined in the specification.

Picolinamide oligomers, preparation method and applications thereof

The invention belongs to the technical field of membrane separation, and more specifically relates to picolinamide oligomers, a preparation method and applications thereof. The picolinamide oligomerscomprise the following characteristics: 1. the oligomers

Electrophilic Zinc Homoenolates: Synthesis of Cyclopropylamines from Cyclopropanols and Amines

Metal homoenolates, produced via C-C bond cleavage of cyclopropanols, have been extensively investigated as nucleophiles for the synthesis of β-substituted carbonyl derivatives. Herein, we demonstrate that zinc homoenolates can react as carbonyl-electrophiles in the presence of nucleophilic amines to yield highly valuable trans-cyclopropylamines in good yields and high diastereoselectivities. GSK2879552, a lysine demethylase 1 inhibitor currently in clinical trials for the treatment of small cell lung carcinoma, was synthesized using this strategy.

New calix[4]arene-cored peripherally functionalized dendrimers: Synthesis and conformational characteristics

Abstract New calixarene-based dendrimers, containing calix[4]arene as the core and different generations of Fréchet-type poly(benzyl ether) dendrons as building blocks, which possess either Br-atoms or COOtBu groups at their surface were synthe