428507-38-4Relevant academic research and scientific papers
Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABAA α5 inverse agonist series
Achermann, Guido,Ballard, Theresa M.,Blasco, Francesca,Broutin, Pierre-Emmanuel,Buettelmann, Bernd,Fischer, Holger,Graf, Martin,Hernandez, Maria-Clemencia,Hilty, Peter,Knoflach, Frederic,Koblet, Andreas,Knust, Henner,Kurt, Anke,Martin, James R.,Masciadri, Raffaello,Porter, Richard H.P.,Stadler, Heinz,Thomas, Andrew W.,Trube, Gerhard,Wichmann, Juergen
scheme or table, p. 5746 - 5752 (2010/04/30)
Through iterative design cycles we have discovered a number of novel new classes where the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine was deemed the most promising GABAA α5 inverse agonist class with potential for cognitive enhanc
Substituted imidazo [1,5-a] [1,2,4] triazolo [4,3-d] [1,4] benzodiazepine derivatives
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, (2008/06/13)
The present invention is a compound of formula The compound and derivatives or pharmaceutically acceptable salts thereof of the invention have a good affinity and selectivity to the GABA A α5 receptor and are useful for the treatment of diseases related t
