428514-88-9Relevant academic research and scientific papers
Synthesis of chiral nonracemic 1-(2-pyridinyl)ethylamines: Stereospecific introduction of amino function onto the 2-pyridinylmethyl carbon center
Uenishi, Jun'ichi,Hamada, Masahiro,Aburatani, Sachiko,Matsui, Katsuya,Yonemitsu, Osamu,Tsukube, Hiroshi
, p. 6781 - 6789 (2007/10/03)
Stereospecific substitutions of optically pure 1-(pyridinyl)ethyl methanesulfonates with various amines are described. The reaction of (R)- or (S)-1-(2-pyridinyl)ethyl methanesulfonate with primary amines, including amino acid esters, gives N-substituted
Preparation of new chiral pyridine-phosphine ligands and their Pd-catalyzed asymmetric allylic alkylations
Uenishi, Jun'ichi,Hamada, Masahiro
, p. 2999 - 3006 (2007/10/03)
Enantiomerically pure 2-(diphenylphosphino)methyl-N-[1-(2-pyridinyl)ethyl] 1 and 2 have been prepared by the stereospecific substitution of enantiomerically pure 1-(2-pyridinyl)ethyl methanesulfonate 6 eith enantiomerically pure 2-(diphenylphosphino)methylpyrrolidine. Asymmetric allylic akylation of 1,3-diphenyl-2-propenyl acatate 11 with dimethyl malonate sodium salt using the (S,S)-ligand 1 affords the (R)-product 12 with up to 86% e.e. in good yield.
