428514-90-3Relevant academic research and scientific papers
Preparation of new chiral pyridine-phosphine ligands and their Pd-catalyzed asymmetric allylic alkylations
Uenishi, Jun'ichi,Hamada, Masahiro
, p. 2999 - 3006 (2007/10/03)
Enantiomerically pure 2-(diphenylphosphino)methyl-N-[1-(2-pyridinyl)ethyl] 1 and 2 have been prepared by the stereospecific substitution of enantiomerically pure 1-(2-pyridinyl)ethyl methanesulfonate 6 eith enantiomerically pure 2-(diphenylphosphino)methylpyrrolidine. Asymmetric allylic akylation of 1,3-diphenyl-2-propenyl acatate 11 with dimethyl malonate sodium salt using the (S,S)-ligand 1 affords the (R)-product 12 with up to 86% e.e. in good yield.
