42855-59-4

Upstream product

• 40834-42-2 5-hydroxy-4-methyl-5H-furan-2-one 
• 100-46-9 benzylamine 
• 4383-22-6 Allylbenzylamine 
• 154139-25-0 N-benzyl-N-bromoacetyl-2-propenylamine 
• 85539-55-5 N-allyl-N-benzyl-2-iodoacetamide 
• 201230-82-2 carbon monoxide 
• 85390-58-5 but-3-enoic acid benzylamide 

Relevant academic research and scientific papers

Scalable Synthesis of 3-Ethyl-4-methyl-1,5-dihydro-2 H -pyrrol-2-one: An Important Building Block of the Antidiabetic Drug Glimepiride

A four-step, practical, and easily scalable synthesis of 3-ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one, an important building block of the antidiabetic drug glimepiride, has been accomplished. Key features are the synthesis of 3-methyl-4-hydroxy-2-butenolide in water and triflic acid mediated N-benzyl lactam N-deprotection. The main advantages of this process are the scalable synthetic route and decreased number of reaction steps, which paves the way for the industrial-scale synthesis of 3-ethyl-4-methyl-1,5-dihydro-2H-pyrrol-2-one.

Synthesis of γ-Butyrolactams by the Palladium-Catalyzed Cyclization of N-Allylbromoacetamides

N-Allylbromoacetamides undergo cyclizatlon to give γ-butyrolactams in the presence of palladium catalysts and a base. - Key words: Palladium-catalyzed cyclization; γ-Butyrolactam.

New Synthesis of Nitrogen Heterocycles through Amide-Directed Hydrocarbonylation of Alkenamides Catalyzed by Rhodium Complexes

Amide-directed hydrocarbonylation of 3-butenamide (1) catalyzed by rhodium complexes such as RhCl(PPh3)3, RhCl(CO)(PPh3)2, HRh(CO)(PPh3)3, and Rh4(CO)12 gives a mixture of 3,4-dihydro-2-pyridone (2), 4-methyl-3-pyrrolin-2-one (3), and a unique heterodimer

NEW ROUTES TO NITROGEN HETEROCYCLES THROUGH INTRAMOLECULAR AMIDOCARBONYLATON OF ALKENAMIDES CATALYZED BY RHODIUM COMPLEXES

Intramolecular amidocarbonylation of 3-butenamide catalyzed by a rhodium complex with excess PPh3 gives 3,4-dihydro-2-pyridone selectively, whereas the same reaction using P(OPh)3 affords a unique heterodimer in excellent yield.The reaction of 4-pentenamide gives 4-methyl-3,4-dihydro-2-pyridone exclusively regardless of the structure of rhodium catalysts.

New synthesis of heterocycles by use of palladium catalyzed cycli zation of α-haloamide with internal double bond

α-Haloamide having internal double bond was allowed to react with a catalytic amount of Pd(PPh3)4 in the presence of base to produce a cyclized product in a fairly good yield possibly through the intermediate of -alkylmetal complex. By use of this method, five and six membered lactams, pyrrolizidine and quinolizidine derivatives were synthesized in fairly good yields.

CYCLIZATION OF α-HALOAMIDE WITH INTERNAL DOUBLE BOND BY USE OF THE LOW-VALENT METAL COMPLEX

The α-haloamide having internal double bond was allowed to react with a catalytic amount of Pd(PPh3)4 in the presence of proton sponge to produce a cyclized product in a fairly good yield possibly through the intermediation of ?-alkylmetal complex althoug