85539-55-5Relevant academic research and scientific papers
New synthesis of heterocycles by use of palladium catalyzed cycli zation of α-haloamide with internal double bond
Mori, Miwako,Kanda, Nana,Oda, Izumi,Ban, Yoshio
, p. 5465 - 5474 (1985)
α-Haloamide having internal double bond was allowed to react with a catalytic amount of Pd(PPh3)4 in the presence of base to produce a cyclized product in a fairly good yield possibly through the intermediate of -alkylmetal complex. By use of this method, five and six membered lactams, pyrrolizidine and quinolizidine derivatives were synthesized in fairly good yields.
Expedient synthesis of 2-oxopiperazines using a SN2 / Cope-type hydroamination sequence
Das Neves, Nicolas,Raymond, Micha?l,Beauchemin, André M.
, p. 639 - 650 (2016/11/13)
An approach for the synthesis of 2-oxopiperazines from allylic 2-iodoacetamides and aqueous NH2OH has been developed. The reaction proceeds through a SN2 / intramolecular Cope-type hydroamination sequence yielding in 2-oxopiperazines
