42865-75-8

Usage

Uses

Used in Pharmaceutical Synthesis:
Ethanone, 1-[3-(methylamino)phenyl](9CI) is used as a key intermediate in the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows for the creation of a wide range of molecules with diverse therapeutic applications.
Used in Medicinal Chemistry Research:
Ethanone, 1-[3-(methylamino)phenyl](9CI) is also utilized in medicinal chemistry research for its potential pharmacological properties. Ethanone, 1-[3-(methylamino)phenyl](9CI) has been studied for its analgesic effects, making it a candidate for the development of pain relief medications.
Used in Neurological Disorder Treatment:
Furthermore, Ethanone, 1-[3-(methylamino)phenyl](9CI) has been explored for its anticonvulsant properties, indicating its potential use in the treatment of neurological disorders such as epilepsy and other seizure-related conditions.

Upstream product

• 67-56-1 methanol 
• 99-03-6 1-(3-aminophenyl)ethanone 
• 844679-46-5 N-(3-acetylphenyl)-N-methylbenzenesulfonamide 
• 76883-63-1 N-(3-acetylphenyl)benzenesulfonamide 
• 74-88-4 methyl iodide 

Downstream Products

• 56916-13-3 6-(3-methylamino-phenyl)-2-oxo-1,2-dihydro-pyridine-3-carbonitrile 
• 1488332-09-7 C₁₇H₁₇NO₂ 
• 1488332-28-0 C₁₇H₁₅NO 
• 1019209-81-4 N-(3-acetylphenyl)-N-methyl-4-nitrobenzamide 
• 1019209-80-3 N-(3-acetylphenyl)-N-methyl-4-fluorobenzamide 
• 1019209-86-9 1-[3-[(2-fluoroethyl)methylamino]phenyl]ethanone 
• 50838-45-4 (3-Acetyl-phenyl)-methyl-thiocarbamic acid O-(1,2,3,4-tetrahydro-1,4-methano-naphthalen-6-yl) ester 

Relevant academic research and scientific papers

Transition-Metal-Free and Visible-Light-Mediated Desulfonylation and Dehalogenation Reactions: Hantzsch Ester Anion as Electron and Hydrogen Atom Donor

Novel approaches for N- and O-desulfonylation under room temperature (rt) and transition-metal-free conditions have been developed. The first methodology involves the transformation of a variety of N-sulfonyl heterocycles and phenyl benzenesulfonates to the corresponding desulfonylated products in good to excellent yields using only KOtBu in dimethyl sulfoxide (DMSO) at rt. Alternately, a visible light method has been used for deprotection of N-methyl-N-arylsulfonamides with Hantzsch ester (HE) anion serving as the visible-light-absorbing reagent and electron and hydrogen atom donor to promote the desulfonylation reaction. The HE anion can be easily prepared in situ by reaction of the corresponding HE with KOtBu in DMSO at rt. Both protocols were further explored in terms of synthetic scope as well as mechanistic aspects to rationalize key features of desulfonylation processes. Furthermore, the HE anion induces reductive dehalogenation reaction of aryl halides under visible light irradiation.

Rhodium(iii)-catalyzed indole synthesis at room temperature using the transient oxidizing directing group strategy

Rh-catalyzed reactions of N-alkyl anilines with internal alkynes at room temperature have been developed using an in situ generated N-nitroso group as a transient oxidizing directing group. Due to mild reaction conditions, this method enabled synthesis of a broad range of N-alkyl indoles, including even two indole-based medicinal compounds. Our work disclosed the feasibility of the transient oxidizing directing group strategy in C-H functionalization reactions, which possesses the potential to enhance overall step-economy and impart new reactivity patterns to substrates.

Guanidino-heterocyclyl-phenyl-amidines and salts thereof

Compounds of the tautomeric formula STR1 wherein R, R1 and R2, which may be identical to or different from each other, are each hydrogen or alkyl of 1 to 4 carbon atoms; R3 is straight or branched alkyl, optionally interru

Novel antibacterial amide compounds and process means for producing the same

Novel organic amide compounds which are N-[6-[(substituted amino)phenyl]-1,2-dihydro-2-oxonicotinyl]penicillin and cephalosporin type compounds having broad spectrum antibacterial utility are provided by (a) reacting the free amino acid of the appropriate penicillin or cephalosporin or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding N-6-[(substituted amino)phenyl]-1,2-dihydro-2-oxonicotinic acid or (b) reacting the free amino acid 6-amino-penicillanic acid, 7-aminocephalosporanic acid, 7-amino-3-methylceph-3-em-4-carboxylic acid or a related compound or the acid salt or silylated derivative thereof with a reactive derivative of the corresponding D-N-[6-[(substituted amino)phenyl]-1,2-dihydro-2-oxonicotinyl]-2-substituted glycine. Pharmaceutical compositions containing said compounds and methods for treating infections using said compositions are also disclosed.