42866-38-6Relevant academic research and scientific papers
Synthesis of azomethines derived from cinnamaldehyde and vanillin: in vitro aetylcholinesterase inhibitory, antioxidant and insilico molecular docking studies
Chigurupati, Sridevi,Selvaraj, Manikandan,Mani, Vasudevan,Mohammad, Jahidul I.,Selvarajan, Kesavanarayanan K.,Akhtar, Shaikh S.,Marikannan, Maharajan,Raj, Suthakaran,Teh, Lay K.,Salleh, Mohd Z.
, p. 807 - 816 (2017/11/16)
In the present study, we report the synthesis of azomethines derived from cinnamaldehyde (C1–C3) and vanillin (V1–V3) using ethanol as a green solvent in the presence of triethyl amine. The synthesized compounds were characterized and investigated for the
Synthesis, structure-activity relationships and preliminary mechanism study of N-benzylideneaniline derivatives as potential TLR2 inhibitors
Cai, Shaoyi,Zhu, Gengzheng,Cen, Xiaohong,Bi, Jingjie,Zhang, Jingru,Tang, Xiaoshan,Chen, Kun,Cheng, Kui
, p. 2041 - 2050 (2018/03/13)
Toll-like receptor 2 (TLR2) can recognize pathogen-associated molecular patterns to defense against invading organisms and has been represents an attractive therapeutic target. Until today, none TLR2 small molecule antagonist have been developed in clinic
Antioxidant activities and transition metal ion chelating studies of some hydroxyl Schiff base derivatives
Zhang, Ye,Zou, Biqun,Wang, Kai,Pan, Yingming,Liang, Hong,Yi, Xianghui,Wang, Hengshan
experimental part, p. 1341 - 1346 (2012/08/27)
Several hydroxyl Schiff base (HSB) compounds (1-10) with good radical scavenging activity (RSA) were designed. Compounds 6, 7, and 10 showed better RSAs than the common synthetic antioxidant 2,6-diterbutyl- 4-methylphenol (BHT) in DPPH and ABTS assays. To probe whether these HSB compounds may exert their antioxidant effect through transition metal ion chelation, the copper and ferrous chelating abilities of them were investigated. It was found by fluorescence quenching spectra that the binding constants Ka were in the range of 0.85×103-7.30×104 M-1. Further study was carried out by the complexation of a representative compound 5 with ferrous ion in mass spectrum. A 2:1 5-ferrous complex was readily formed in a methanol-water solution (v:v, 8:2), which confirmed that the chelation happened when the HSB compounds were treated with transition metal ions. The above results indicated that the transition metal ion chelation play an important role in their antioxidant abilities. Springer Science+Business Media, LLC 2011.
Reagents and Synthetic Methods. Part 58. Synthesis of β-Lactams from Acetic Acids and Imines promoted by Vilsmeier Type Reagents
Arrieta, Ana,Lecea, Begona,Palomo, Claudio
, p. 845 - 850 (2007/10/02)
The development of a practical method for the stereospecific preparation of several 3-substituted β-lactams from acetic acids and imines is described.The key step of the method is the activation of the carboxy component by means of Vilsmeier type reagents.The preparation of some N-(2'-hydroxyethyl)-β-lactams and N-(p-dimethyl-t-butylsiloxyphenyl)-β-lactams as intermediates for N-H azetidinones is also reported.For the last compounds the steric bulk of the N-substituent is the key feature for a high cis-β-lactam formation.
Synthesis of New Polycyclic Carbazoloquinones
Hammam, A. S.,Youssef, M. S. K.,Abbady, M. A.,Ibrahim, R. R.
, p. 565 - 570 (2007/10/02)
Some new policyclic carbazoloquinones, substituted 6H-pyridocarbazoles (V) have been synthesized by the interaction of the Diels-Alder adducts (II), obtained from the addition of cinnamyliden-anils (I) to 4,4-dimethoxyquinone in 1:1 molar ratio, wi
Synthesis, characterization, biological and DFT studies of new 4-substituted phthalonitriles
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, (2019/05/16)
Herein, we describe the synthesis, characterization and computational studies of novel 4-substituted phthalonitriles: (1) 4-(4-((benzothiazole)methyleneamino)phenoxy)phthalonitrile, (2) 4-(4-(3-phenylallylideneamino)phenoxy)phthalonitrile and (3) 4-(4-(4-
