42875-09-2Relevant academic research and scientific papers
Copper-Catalyzed Ring Opening of [1.1.1]Propellane with Alkynes: Synthesis of Exocyclic Allenic Cyclobutanes
Lasányi, Dániel,Tolnai, Gergely L.
supporting information, p. 10057 - 10062 (2019/12/24)
Despite the long history and interesting properties of propellanes, these compounds still have tremendous potential to be exploited in synthetic organic chemistry. Herein we disclose an experimentally simple procedure to achieve cyclobutane-containing allenes and alkynes through a copper-catalyzed ring opening of [1.1.1]propellane and subsequent reaction with ethynes.
Transferrin-Appended Nanocaplet for Transcellular siRNA Delivery into Deep Tissues
Kohata, Ai,Hashim,Okuro, Kou,Aida, Takuzo
supporting information, p. 2862 - 2866 (2019/02/19)
Transferrin (Tf) is known to induce transcytosis, which is a consecutive endocytosis/exocytosis event. We developed a Tf-appended nanocaplet (TfNC?siRNA) for the purpose of realizing siRNA delivery into deep tissues and RNA interference (RNAi)
5-Alkynyl-2′-deoxyuridines, containing bulky aryl groups: Evaluation of structure-anti-HSV-1 activity relationship
Skorobogatyi, Mikhail V.,Pchelintseva, Anna A.,Petrunina, Anna L.,Stepanova, Irina A.,Andronova, Valeriya L.,Galegov, Georgi A.,Malakhov, Andrei D.,Korshun, Vladimir A.
, p. 1279 - 1287 (2007/10/03)
Four 5-alkynyl-2′-deoxyuridines containing different bulky substituents and flexible linkers between the triple bond and the aromatic residue have been prepared and tested against HSV-1 in Vero cells. Two nucleosides containing carbonyl groups, 5-(4-benzo
