428821-32-3Relevant academic research and scientific papers
Stereocontrol at the steady state in radical cyclizations of acyclic dihalides
Stalinski, Krzysztof,Curran, Dennis P.
, p. 2982 - 2988 (2007/10/03)
The first examples of manipulating stereocontrol solely by reaction topography in radical cyclizations starting from acyclic precursors are reported. The kinetic model for acyclic compound stereoselection is verified experimentally by conducting a series of radical cyclizations of 1,3-dihalo-2-(1-phenyl-3-butynyl)propanes with triphenyltin hydride and measuring the ratios of the products. Monohalide intermediates are observed for the first time, and evidence that bromide- and iodide-substituted radicals have different cyclization rate constants is provided.
