428861-79-4Relevant academic research and scientific papers
New series of aryloxypropanolamines with both human β3-adrenoceptor agonistic activity and free radical scavenging properties
Aubriot, Silvere,Nicolle, Edwige,Lattier, Mireille,Morel, Cecile,Cao, Wenhong,Daniel, Kiefer W.,Collins, Sheila,Leclerc, Gerard,Faure, Patrice
, p. 209 - 212 (2002)
A series of 13 novel hybrid molecules designed to possess both free radical scavenging activity and to stimulate the β3-adrenoceptors in order to improve antidiabetic effect and to restore insulin sensitivity was synthesized and evaluated. Compounds were of quinolyl-, isoquinolyl-, pyridoindolyl- or carbazolyloxypropanolamine structure with a terminal amino group of benzopyranolyl-, di-tert-butylphenolyl- or methoxyindolyl-type. Some of the products possessed both the expected activities.
