42887-67-2

Basic information

• Product Name: ETHANONE, 1-(2-AMINO-5-METHOXYPHENYL)-
• Synonyms: 1-(2-AMINO-5-METHOXY-PHENYL)-ETHANONE;ETHANONE, 1-(2-AMINO-5-METHOXYPHENYL)-;1-(5-Methoxy-2-nitro-phenyl)-ethanone
• CAS NO: 42887-67-2
• Molecular Formula: C₉H₉NO₄
• Molecular Weight: 165.18914
• Mol File: 42887-67-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: ETHANONE, 1-(2-AMINO-5-METHOXYPHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: ETHANONE, 1-(2-AMINO-5-METHOXYPHENYL)-(42887-67-2)
• EPA Substance Registry System: ETHANONE, 1-(2-AMINO-5-METHOXYPHENYL)-(42887-67-2)

Safety Data

• Hazardous Substances Data: 42887-67-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
ETHANONE, 1-(2-AMINO-5-METHOXYPHENYL)is utilized as a key intermediate in the synthesis of various pharmaceuticals, contributing to the development of new drugs and enhancing the efficacy of existing ones.
Used in Dye Industry:
ETHANONE, 1-(2-AMINO-5-METHOXYPHENYL)is employed as a precursor in the production of dyes, playing a crucial role in the creation of a diverse range of colorants for various applications.
Used in Organic Chemistry:
ETHANONE, 1-(2-AMINO-5-METHOXYPHENYL)is used as a versatile intermediate in organic chemistry, facilitating the synthesis of a wide array of organic compounds for different industries.
Used in Chemical Industry:
As a component in the production of other organic chemicals, ETHANONE, 1-(2-AMINO-5-METHOXYPHENYL)- is instrumental in the chemical industry, enabling the creation of new materials and products with diverse applications.

Upstream product

• 20357-24-8 5-methoxy-2-nitro-benzaldehyde 
• 1439930-72-9 (E)-1-(5-methoxy-2-nitrophenyl)ethanone O-methyl oxime 
• 121-71-1 3-Hydroxyacetophenone 
• 30879-49-3 1-(5-hydroxy-2-nitrophenyl)ethan-1-one 
• 74-88-4 methyl iodide 
• 42454-06-8 2-nitro-5-hydroxybenzaldehyde 
• 586-37-8 1-(3-Methoxyphenyl)ethanone 
• 156785-62-5 1-(5-methoxy-2-nitrophenyl)ethanol 
• 77-78-1 dimethyl sulfate 
• 63932-00-3 5-methoxy-2-nitrobenzoyl chloride 

Downstream Products

• 1308803-37-3 2-isopropenyl-4-methoxynitrobenzene 
• 1438559-19-3 (6-methoxyquinolin-8-yl)(phenyl)methanone 
• 92210-44-1 (2-acetyl-4-methoxy-phenyl)-carbamic acid ethyl ester 
• 155694-76-1 1-N-acetyl-4-keto-6-methoxy-2-phenyl-3-(phenylseleno)-1,2,3,4-tetrahydroquinoline 
• 156785-64-7 2-<(4-fluorobenzoyl)amino>-5-methoxyacetophenone 
• 156785-65-8 2-(4-fluorophenyl)-5-methoxy-3-methylindole 
• 91444-33-6 1-ethyl-5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole 
• 156785-63-6 5-methoxy-2-<(4-methoxybenzoyl)amino>acetophenone 
• 91444-18-7 5-methoxy-2-(4-methoxyphenyl)-3-methyl-1H-indole 
• 180343-65-1 1-(2-azido-5-methoxyphenyl)ethanone 
• 13788-72-2 6-methoxy-4(1H)-quinolinone 
• 53967-86-5 5-methoxy-3-methyl-benzo[c]isoxazole 
• 32254-66-3 2-dimethylaminomethyl-1-(5-methoxy-2-nitro-phenyl)-propenone; hydrochloride 
• 23042-77-5 1-(2-amino-5-methoxy-phenyl)-ethanone 

Relevant articles and documents

Palladium-catalyzed chelation-assisted aromatic C-H nitration: Regiospecific synthesis of nitroarenes free from the effect of the orientation rules

A palladium-catalyzed chelation-assisted ortho-nitration of aryl C-H bond is described. A range of azaarenes such as 2-arylquinoxalines, pyridines, quinoline, and pyrazoles were nitrated with excellent chemo- and regioselectivity. Using the O-methyl oximyl group as a removable directing group, the regiospecific synthesis of a variety of o-nitro aryl ketones was achieved starting from aryl ketones via a three-step process involving the Pd-catalyzed ipso-nitration of C-H bond as a key step. Mechanistic investigations support a silver-mediated radical mechanism involving Pd((II/III) and/or Pd(II/IV) catalytic cycles under oxidizing conditions.

Direct exchange of a ketone methyl or aryl group to another aryl group through ciC bond activation assisted by rhodium chelation

Swapped: Commercially available quinolinone derivatives (1 or 2, see scheme) were reacted with arylboronic acids in the presence of a RhI complex to give aryl(quinolin-8-yl)methanone products 3 in medium to good yields. A mechanism that involves the in situ oxidation of RhI to RhIII by O2 in the presence of CuI was proposed. Copyright

Ionic diamine rhodium complex catalyzed reductive N-heterocyclization of 2-nitrovinylarenes

Ionic diamine rhodium complex (1) catalyzes the reductive N-cyclization of 2-vinylnitroarenes using carbon monoxide as a reducing agent to afford functionalized indoles. The catalytic system allows direct access to indoles with ester and ketone groups at the 2- or 3-position, in good yields.

Substituent effects on the lifetimes and reactivities of arylnitrenium ions studied by laser flash photolysis and photothermal beam deflection

Photolysis of 5-substituted-N-tert-butyl-3-methylanthranilium ion produces transient N-tert-butyl-(2-acetyl-4-substituted) phenylnitrenium ions. This is confirmed by identification of the stable products, transient absorption experiments, and photothermal

Syntheses of Zindoxifene and Analogues by Titanium-Induced Oxo-Amide Coupling

Highly reactive titanium on graphite is used to reductively cyclize electron-rich acylamino carbonyl compounds 7, 8, 12, 14, and 16 to the corresponding indole derivatives 9, 10, 13, 15, and 17.Compound 9b is a known precursor of the mammary tumor-inhibiting compound zindoxifene (2).The other products are new analogues of this anticancer drug, exhibiting the substitution pattern previously recognized to be essential for high pharmacological activity. - Key Words: Indoles, 2-aryl- / Titanium graphite / Zindoxifene / Tumor-growth inhibitors / Alkylidenation, intramolecular