428879-79-2Relevant academic research and scientific papers
Structure-activity relationships of methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists. 2. Role of polymethylene chain lengths separating amine functions and of substituents on the terminal nitrogen atoms
Rosini, Michela,Bixel, M. Gabriele,Marucci, Gabriella,Budriesi, Roberta,Krauss, Michael,Bolognesi, Maria L.,Minarini, Anna,Tumiatti, Vincenzo,Hucho, Ferdinand,Melchiorre, Carlo
, p. 1860 - 1878 (2007/10/03)
Polymethylene tetraamine methoctramine (1) is a prototypical antimuscarinic ligand endowed with a significant affinity for muscular nAChRs. Thus, according to the universal template approach, structural modifications were performed on 1 in order to improv
