42923-76-2

Basic information

• Product Name: 6-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE
• Synonyms: 6-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE;6-Methyl-1,2,3,4-tetrahydro-isoquinoline hydrochloride
• CAS NO: 42923-76-2
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.22
• Mol File: 42923-76-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 249.649 °C at 760 mmHg
• Flash Point: 107.944 °C
• Appearance: /
• Density: 0.991 g/cm³
• Vapor Pressure: 0.023mmHg at 25°C
• Refractive Index: 1.54
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 6-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(42923-76-2)
• EPA Substance Registry System: 6-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE(42923-76-2)

Safety Data

• Hazardous Substances Data: 42923-76-2(Hazardous Substances Data)

Usage

General Description

6-Methyl-1,2,3,4-tetrahydro-isoquinoline is a chemical compound with a bicyclic structure and a methyl group attached to the nitrogen atom. It is a derivative of isoquinoline, a heterocyclic aromatic organic compound. This chemical is commonly found in plants such as Peganum harmala and is also a known alkaloid. It has been studied for its potential pharmacological properties, including being investigated for its role in neuroprotection and neurodegenerative diseases. Additionally, 6-Methyl-1,2,3,4-tetrahydro-isoquinoline is also used as a precursor in the synthesis of various pharmaceutical compounds.

InChI:InChI=1/C10H13N/c1-8-2-3-10-7-11-5-4-9(10)6-8/h2-3,6,11H,4-5,7H2,1H3

Upstream product

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• 861328-39-4 2-benzenesulfonyl-6-methyl-1,2,3,4-tetrahydro-isoquinoline 

Downstream Products

• 1430217-51-8 (E)-methyl 4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-6-methyl-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoate 
• 1430216-12-8 (E)-4-(2-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acryloyl)-6-methyl-1,2,3,4-tetrahydroisoquinoline-1-carboxamido)benzoic acid 
• 943339-21-7 2-(3-(3-chlorophenyl)propiolyl)-6-methyl-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

PRMT5 INHIBITORS

The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.

SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS

The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.

SUBSTITUTED PROPIOLIC ACID AMIDES AND THEIR USE FOR PRODUCING DRUGS

The present invention relates to substituted propiolic acid amides, to methods for the production thereof, to medicaments containing these compounds and to the use thereof for producing medicaments.