42927-35-5

Upstream product

• 13074-06-1 L-fucitol 
• 73679-53-5 (E,4'S,5'S)-ethyl 3-(2',2',5'-trimethyl-1',3'-dioxolan-4'-yl)acrylate 
• 67-64-1 acetone 
• 198009-56-2 ethyl (2E,4S,5S)-4,5-dihydroxy-2-hexenoate 
• 2396-84-1 (2E,4E)-ethyl hexa-2,4-dienoate 
• 848566-30-3 (2S,3S)-ethyl 2,3-dihydroxy-3-((4'S,5'S)-2',2',5'-trimethyl-1',3'-dioxolan-4'-yl)propanoate 
• 849775-41-3 (2S,3R)-ethyl 2,2-dimethyl-5-((4'R,5'S)-2',2',5'-trimethyl-1',3'-dioxolan-4'-yl)-1,3-dioxolane-4-carboxylate 

Downstream Products

• 42927-36-6 O²,O³;O⁴,O⁵-diisopropylidene-O⁶-(toluene-4-sulfonyl)-D-1-deoxy-galactitol 

Relevant academic research and scientific papers

Enantioselective synthesis of 10-epi-anamarine via an iterative dihydroxylation sequence

(Chemical Equation Presented) The enantioselective syntheses of 10-epi-anamarine and 5,10-epi,epi-anamarine have been achieved in 13 to 14 steps. The route relies upon an enantio- and regioselective Sharpless dihydroxylation of either dienoates or trienoates to establish the C-8 to C-11 stereochemistry. A diastereoselective Leighton allylation established the desired C-5 stereochemistry. The route also relies upon a ring-closing metathesis to establish the α,β-unsaturated lactones.

METHOD FOR PRODUCING L-FUCOSE

Method for producing L-fucose includes in a first aspect, a method for the preparation of L-fucose, wherein L-fucose precursors are produced from pectin and L-fucose is produced from the L-fucose precursors; in a second aspect, a method for the preparation of L-fucose from D-galacturonic acid or a salt thereof, wherein L-fucose precursors are produced from D-galacturonic acid of a salt thereof, and L-fucose is produced from the L-fucose precursors; and an L-fucose precursor as shown in Formula A, wherein R is a linear or branched chain saturated hydrocarbon group with 1-6 carbon atoms, such as methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, t-butyl, n-hexyl, etc., preferably a methyl group.

METHOD FOR PRODUCING L-FUCOSE

The present invention provides: in a first aspect, a method for the preparation of L-fucose, wherein L-fucose precursors are produced from pectin and L-fucose is produced from the L-fucose precursors; in a second aspect, a method for the preparation of L-fucose from D-galacturonic acid or a salt thereof, wherein L-fucose precursors are produced from D-galacturonic acid or a salt thereof, and L-fucose is produced from the L-fucose precursors; and an L-fucose precursoras shown in Formula A below, wherein R is a linear or branched chain saturated hydrocarbon group with 1-6 carbon atoms, such as methyl, ethyl, n-propyl, i-propyl, n-butyl, i-butyl, s-butyl, t-butyl, n-hexyl, etc., preferably a methyl group.

De novo asymmetric synthesis of anamarine and its analogues

The enantioselective synthesis of anamarine has been achieved in 21 steps. The route relies on enantio- and regioselective Sharpless dihydroxylation of dienoate ester and zinc borohydride reduction to establish the C-8-C-11 stereochemistry. A diastereosel