42945-78-8

Usage

Uses

Used in Chemical Synthesis:
Ethanethione, 2-(4-Methoxyphenyl)-1-(4-Morpholinyl)is used as a building block in the synthesis of more complex organic molecules, leveraging its thioether properties and functional groups for the creation of diverse chemical entities.
Used in Fragrance Industry:
Due to its characteristic scent, Ethanethione, 2-(4-Methoxyphenyl)-1-(4-Morpholinyl)can be employed as a fragrance ingredient, contributing to the development of unique olfactory profiles in perfumes, cosmetics, and other scented products.
Used in Pharmaceutical Industry:
Ethanethione, 2-(4-Methoxyphenyl)-1-(4-Morpholinyl)may be utilized in the pharmaceutical sector as an intermediate in the synthesis of therapeutic agents, potentially offering novel pharmacological properties and applications in drug discovery and development.
Used in Research and Development:
In the field of scientific research, Ethanethione, 2-(4-Methoxyphenyl)-1-(4-Morpholinyl)serves as a valuable compound for studying the properties and reactivity of thioethers, as well as exploring its potential in various chemical reactions and applications.

InChI:InChI=1/C13H17NO2S/c1-15-12-4-2-11(3-5-12)10-13(17)14-6-8-16-9-7-14/h2-5H,6-10H2,1H3

Upstream product

• 110-91-8 morpholine 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 717-14-6 4-methoxyacetophenone semicarbazone 

Downstream Products

• 113769-77-0 3-(4-methoxyphenyl)-6-methyl-2H-chromen-2-one 
• 23000-33-1 3-(4-methoxyphenyl)coumarin 
• 59276-88-9 8-methoxy-3-(4-methoxyphenyl)-2H-chromen-2-one 
• 126572-92-7 4-[(E)-2-(4-Methoxy-phenyl)-1-(2-nitro-phenyldisulfanyl)-2-(2-nitro-phenylsulfanyl)-vinyl]-morpholine 
• 113769-78-1 2-(4-methoxyphenyl)-3H-benzo[f]chromen-3-one 
• 99378-53-7 4-[2-(4-Methoxy-phenyl)-1-(4-nitro-benzylsulfanyl)-ethylidene]-morpholin-4-ium; bromide 
• 781654-24-8 (4-hydroxyphenyl)thioacetomorpholide 
• 99931-94-9 2-(4-methoxyphenyl)-1-morpholinoethan-1-one 
• 104-01-8 4-Methoxyphenylacetic acid 
• 476005-57-9 methyl 2-[(Z)-4-(4-methoxyphenyl)-5-morpholino-3-oxo-2,3-dihydrothiophen-2-ylidene]acetate 
• 880294-33-7 C₁₈H₁₉NO₅S 
• 1393898-14-0 4-(4-methoxyphenyl)-5-(morpholin-4-yl)-3-phenylthiophen-2(3H)-one 
• 100372-92-7 1-(4-methoxyphenyl)-2-morpholino-2-thioxo-1-ethanone 
• 99378-61-7 4-[3-(4-Methoxy-phenyl)-5-(4-nitro-phenyl)-thiophen-2-yl]-morpholine 

Relevant academic research and scientific papers

A versatile one-pot synthesis of 2,3,5-tri-substituted thiophenes from thiomorpholides

An efficient method for the preparation of 2,3,5-trisubstituted thiophenes in a one-pot synthesis from thiomorpholides via the thio-Claisen rearrangement was developed.

Sulfated tungstate: A green catalyst for synthesis of thiomorpholides via Willgerodt-Kindler reaction

Use of sulfated tungstate as an efficient, green and reusable catalyst for preparation of thiomorpholides via Willgerodt-Kindler reaction pathway is presented. The reaction proceeds under solvent free condition. The advantages of this method are high yiel

Ultrasound-mediated willgerodt-kindler reactions: Non-thermal synthesis of thioacetamides

Non-thermal, solvent-free condensation of several aryl methyl ketones with amines and elemental sulfur is efficiently conducted using ultrasonic irradiation within short time periods. Consequently, various thioacetamides are conveniently synthesized. Simi

Silica-supported fluoroboric acid (HBF4-SiO2) catalyzed highly productive synthesis of thiomorpholides as activators of l-asparaginase as well as the antioxidant agent

An efficient solvent-free procedure for the synthesis of thiomorpholides in the presence of a catalytic amount of solid-supported fluoroboric acid (HBF4-SiO2) is described. The advantages of this method are high yields, short reaction times, ease of product isolation, low cost, and the catalyst can be recycled for a number of times without significant loss of activity. Three thiomorpholides possessing electron-donating group (4c, 4g, and 4h) were exhibiting excellent stimulatory activities against Erwinia carotovora l-asparaginase. The most potent activator, compound 4h displayed the following kinetic parameters, Km = 75 μM and Vmax = 1000 μmol mg-1 min-1 and KA = 0.985 μM. Furthermore, these compounds (4g, 4h, 4c, 4f, 4a, and 4d) have also shown promising 2,2′-diphenyl-1-picrylhydrazyl (DPPH) reducing antioxidant activity (21-36%) at 1 mM concentration as compared to standard butylated hydroxyl anisole (72% at 1 mM).

THIAZOLE AND THIOPHENE ANALOGUES, AND THEIR USE IN TREATING AUTOIMMUNE DISEASES AND CANCERS

Thiazole and thiophene compounds are disclosed having utility in treating inflammatory conditions, immunoinflammatory conditions, autoimmune diseases, and cancers. Methods for the synthesis of these compounds are also disclosed.

Willgerodt-kindler's microwave-enhanced synthesis of thioamide derivatives

The Willgerodt-Kindler reaction was applied to a series of aromatic aldehydes and ketones. The reactions were performed in a dipolar aprotic solvent (mainly DMF) in the presence of a base catalyst (4-methylmorpholine) and utilized microwave (mw) irradiation. The pulsed mw technique rather than the continuous irradiation was preferred because it limited side reactions and hydrogen sulfide production. While not always superior to the thermal activation of the reaction, the procedure involving repetitive short pulses of microwave irradiation was found to be faster and result in consistently cleaner products. The technique can be easily applied in a fast parallel synthesis process.

Extension of the Willgerodt-Kindler reaction: Protected carbonyl compounds as efficient substrates for this reaction

Nitrogen derivatives of carbonyl compounds such as oximes, hydrazones, and semicarbazones were found to be excellent candidates for the Willgerodt-Kindler reaction. They can be used directly in a solvent-free reaction, under both classical and microwave conditions, to give the corresponding thiomorpholides in good yields.

A facile synthesis of phenylacetic acids via Willgerodt-Kindler reaction under PTC condition

Phenylacetic acids are efficiently synthesized from acetophenones via thiomorpholides under Phase Transfer Catalytic (PTC) condition. The reaction proceeds efficiently by using triethyl benzyl ammonium chloride (TEBA) as PTC and the reaction time decreased dramatically upto 1/5th (24-5) to afford pure products in good to excellent yield.

Reactions of N,N-(dialkyl)arylthioacetamides with dialkyl acetylenedicarboxylates

2-(Alkoxycarbonylmethylidene)-4-aryl-5-(dialkylamino)thiophen-3(2H)-ones were synthesized by condensation of N,N-(dialkyl)arylthioacetamides with dialkyl acetylenedicarboxylates. Intermediate substituted vinylic sulfides were isolated. When heated or in t