4295-99-2

Usage

Uses

Tetrahydro-2H-Pyran-4-Carbonitrile is used in preparation of substituted Amide compounds as farnesoid X receptor modulators.

InChI:InChI=1/C6H9NO/c7-5-6-1-3-8-4-2-6/h6H,1-4H2

Upstream product

• 50675-18-8 3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde 

Downstream Products

• 854696-45-0 cyclohexyl(tetrahydro-2H-pyran-4-yl)methanone 
• 639468-72-7 phenyl(tetrahydro-2H-pyran-4-yl)methanone 
• 130290-79-8 4-tetrahydropyranmethylamine 
• 137052-08-5 1-(tetrahydro-2H-pyran-4-yl)ethan-1-one 
• 7464-18-8 1-(tetrahydro-2H-pyran-4-yl)propan-1-one 
• 916508-97-9 C₁₃H₁₇NO₂ 
• 7403-84-1 1-tetrahydropyran-4-yl-butan-1-one semicarbazone 
• 7502-01-4 4-methyl-1-tetrahydropyran-4-yl-pentan-1-one semicarbazone 
• 7403-99-8 1-tetrahydropyran-4-yl-heptan-1-one semicarbazone 
• 92325-74-1 1-tetrahydropyran-4-yl-propan-1-one-(2,4-dinitro-phenylhydrazone) 
• 93046-48-1 1-tetrahydropyran-4-yl-pentan-1-one-(2,4-dinitro-phenylhydrazone) 
• 96978-43-7 1-tetrahydropyran-4-yl-hexan-1-one-(2,4-dinitro-phenylhydrazone) 
• 141336-88-1 4-[[4-(2-Hydroxyethyl)phenyl]methyl]tetrahydropyran-4-carbonitrile 
• 50675-18-8 3,4,5,6-tetrahydro-2H-pyran-4-carbaldehyde 

Relevant academic research and scientific papers

An efficient catalytic method for the Beckmann rearrangement of ketoximes to amides and aldoximes to nitriles mediated by propylphosphonic anhydride (T3P)

An efficient method for the Beckmann rearrangement of ketoximes to amides mediated by a catalytic amount (15 mol %) of propylphosphonic anhydride (T3P) is described. Aldoximes underwent second order Beckmann rearrangement to provide the corresponding nitriles in excellent yields on reacting with T3P (15 mol %) at room temperature. The main advantages of this environmentally friendly protocol include procedural simplicity, and particularly ease of isolation of the products.

A practical and cost-efficient, one-pot conversion of aldehydes into nitriles mediated by 'activated DMSO'

Participation of activated DMSO in the one-pot transformation of aldehydes to nitriles has been described by reacting aldehydes with NHHHCl in DMSO in the absence of any added base or catalyst. The method is applicable to access a wide range of aromatic, heterocyclic, and aliphatic nitriles, in which only water is a byproduct. A straightforward and practical procedure is demonstrated on a multigram scale. Georg Thieme Verlag Stuttgart - New York.