137052-08-5

Basic information

• Product Name: 1-(Tetrahydro-2H-pyran-4-yl)ethanone
• Synonyms: ACP;4-ACETYLTETRAHYDRO-4H-PYRAN;1-ACETOXY-3-CARBAMOYL,2,2,5,5-TETRAMETHYLPYRROLIDINE;Ethanone, 1-(tetrahydro-2H-pyran-4-yl)- (9CI);Ethanone, 1-(tetrahydro-2H-pyran-4-yl);1-(tetrahydro-2H-pyran-4-yl)ethanone;1-Tetrahydropyran-4-yl-ethanone;1-(Tetrahydro-2H-pyran-4-yl)ethan-1-one, 4-Acetyloxane
• CAS NO: 137052-08-5
• Molecular Formula: C₇H₁₂O₂
• Molecular Weight: 128.17
• EINECS: 809-972-8
• Product Categories: ACETYLGROUP
• Mol File: 137052-08-5.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 90-94℃/15mm
• Flash Point: 75.121 °C
• Appearance: Colorless to pale yellow/Liquid
• Density: 1.024
• Vapor Pressure: 0.381mmHg at 25°C
• Refractive Index: 1.4530
• Storage Temp.: -20°C
• CAS DataBase Reference: 1-(Tetrahydro-2H-pyran-4-yl)ethanone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(Tetrahydro-2H-pyran-4-yl)ethanone(137052-08-5)
• EPA Substance Registry System: 1-(Tetrahydro-2H-pyran-4-yl)ethanone(137052-08-5)

Safety Data

• Hazard Codes: Xn
• Statements: 42-36
• Safety Statements: 22-45-26
• Hazardous Substances Data: 137052-08-5(Hazardous Substances Data)

Usage

General Description

1-(Tetrahydro-2H-pyran-4-yl)ethanone, also known as γ-tetralone, is a chemical compound with a unique molecular structure that includes a tetrahydro-2H-pyran ring and an ethanone group. It is commonly used in the synthesis of various pharmaceuticals and organic compounds due to its versatile reactivity. γ-tetralone is a colorless liquid with a pleasant odor and is soluble in water, making it an ideal candidate for use in chemical reactions. It is also used as a flavoring agent and fragrance in the food and cosmetic industries. Additionally, it has been studied for its potential pharmacological properties, particularly in the treatment of neurological disorders and as an analgesic agent.

InChI:InChI=1/C7H12O2/c1-6(8)7-2-4-9-5-3-7/h7H,2-5H2,1H3

Upstream product

• 40191-32-0 tetrahydro-2H-pyran-4-carbonylchloride 
• 18815-73-1 methylzinc iodide 
• 141-97-9 ethyl acetoacetate 
• 111-44-4 3-oxa-1,5-dichloropentane 
• 110238-91-0 tetrahydropyran-4-carboxylic acid methyl ester 
• 75-16-1 methylmagnesium bromide 
• 156353-01-4 N-methoxy-N-methyltetrahydro-2H-pyran-4-carboxamide 
• 5337-03-1 tetrahydro-2H-pyran-4-carboxylic acid 
• 676-58-4 methylmagnesium chloride 
• 917-54-4 methyllithium 
• 4295-99-2 tetrahydro-2H-pyran-4-carbonitrile 
• 345216-96-8 methyl 4-acetyl-tetrahydro-2H-pyran-4-carboxylate 

Downstream Products

• 75338-17-9 3-oxo-3-(tetrahydropyran-4-yl)propionic acid methyl ester 
• 1295521-50-4 4-(1-(2-pyrrolidin-1-yl-ethyl)-4-(tetrahydro-pyran-4-yl)-1H-imidazol-2-yl)-piperidine 
• 1604039-54-4 trimethyl((tetrahydro-2H-pyran-4-yl)ethynyl)silane 

Relevant articles and documents

Synthesis method for synthesizing 4-ethynyl-tetrahydropyran from 2, 2-dichloroethyl ether

The invention provides a synthetic method for synthesizing 4-ethynyl-tetrahydropyran from 2, 2 '-dichloroethyl ether, which comprises the following steps: (a) reacting a compound shown in a formula (I) with ethyl acetoacetate under the action of potassium carbonate and potassium iodide, carrying out aftertreatment, and carrying out sulfuric acid decarboxylation to obtain a compound shown in a formula (II); (b) removing hydrogen from the compound shown in the formula (II) by using an organic lithium reagent, and reacting with a diester chlorophosphate reagent to obtain a compound shown in a formula (III); and (c) removing the compound shown in the formula (III) by using an alkaline reagent, and reacting with alkyl chlorosilane to obtain a compound shown in a formula (IV). According to the preparation method, starting raw materials, process routes and post-treatment processes are different, the raw materials are simple and easy to obtain, the cost is low, and the preparation method is suitable for laboratory small-scale preparation and industrial production.

PENTAFLUOROSULFUR IMINO HETEROCYCLIC COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE

In its many embodiments, the present invention provides certain pentafluorosulfur imino heterocyclic compounds, including compounds Formula (a) and pharmaceutically acceptable salts thereof. Compounds of Formula (a) have the general structure: (a) wherein each variable is selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Abeta) protein, including Alzheimers Disease, are also disclosed.

PENTAFLUOROSULFUR IMINO HETEROCYCLIC COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS AND THEIR USE

In its many embodiments, the present invention provides certain pentafluorosulfur imino heterocyclic compounds, including compounds Formula (a) and pharmaceutically acceptable salts thereof. Compounds of Formula (a) have the general structure: (a) wherein each variable is selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimers Disease, are also disclosed.