137052-08-5Relevant articles and documents
Synthesis method for synthesizing 4-ethynyl-tetrahydropyran from 2, 2-dichloroethyl ether
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Paragraph 0033; 0036-0038; 0042-0044; 0047-0049; 0052-0054, (2021/03/31)
The invention provides a synthetic method for synthesizing 4-ethynyl-tetrahydropyran from 2, 2 '-dichloroethyl ether, which comprises the following steps: (a) reacting a compound shown in a formula (I) with ethyl acetoacetate under the action of potassium carbonate and potassium iodide, carrying out aftertreatment, and carrying out sulfuric acid decarboxylation to obtain a compound shown in a formula (II); (b) removing hydrogen from the compound shown in the formula (II) by using an organic lithium reagent, and reacting with a diester chlorophosphate reagent to obtain a compound shown in a formula (III); and (c) removing the compound shown in the formula (III) by using an alkaline reagent, and reacting with alkyl chlorosilane to obtain a compound shown in a formula (IV). According to the preparation method, starting raw materials, process routes and post-treatment processes are different, the raw materials are simple and easy to obtain, the cost is low, and the preparation method is suitable for laboratory small-scale preparation and industrial production.
PENTAFLUOROSULFUR IMINO HETEROCYCLIC COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS, AND THEIR USE
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, (2016/08/17)
In its many embodiments, the present invention provides certain pentafluorosulfur imino heterocyclic compounds, including compounds Formula (a) and pharmaceutically acceptable salts thereof. Compounds of Formula (a) have the general structure: (a) wherein each variable is selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Abeta) protein, including Alzheimers Disease, are also disclosed.
PENTAFLUOROSULFUR IMINO HETEROCYCLIC COMPOUNDS AS BACE-1 INHIBITORS, COMPOSITIONS AND THEIR USE
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, (2012/08/08)
In its many embodiments, the present invention provides certain pentafluorosulfur imino heterocyclic compounds, including compounds Formula (a) and pharmaceutically acceptable salts thereof. Compounds of Formula (a) have the general structure: (a) wherein each variable is selected independently and as defined herein. Pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimers Disease, are also disclosed.