42966-95-0

Basic information

• Product Name: 1,3,4-OXADIAZOLE, 2-(2-METHOXYPHENYL)-
• Synonyms: 1,3,4-OXADIAZOLE, 2-(2-METHOXYPHENYL)-;2-(2-METHOXYPHENYL)-1,3,4-OXADIAZOLE
• CAS NO: 42966-95-0
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.17
• Mol File: 42966-95-0.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 307.689°C at 760 mmHg
• Flash Point: 139.885°C
• Appearance: /
• Density: 1.191g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.534
• CAS DataBase Reference: 1,3,4-OXADIAZOLE, 2-(2-METHOXYPHENYL)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,4-OXADIAZOLE, 2-(2-METHOXYPHENYL)-(42966-95-0)
• EPA Substance Registry System: 1,3,4-OXADIAZOLE, 2-(2-METHOXYPHENYL)-(42966-95-0)

Safety Data

• Hazardous Substances Data: 42966-95-0(Hazardous Substances Data)

Usage

General Description

1,3,4-Oxadiazole, 2-(2-methoxyphenyl)- is a chemical compound with the molecular formula C9H8N2O. It is a heterocyclic aromatic organic compound containing an oxygen atom and two nitrogen atoms. This chemical is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals due to its potential biological activities. Its derivative compounds have shown potential antifungal, antibacterial, antiviral, and antitumor activities. 1,3,4-Oxadiazole, 2-(2-methoxyphenyl)- is also used in the production of dyes, pigments, and as a stabilizer in the manufacture of plastics and rubber. It is important to handle this chemical with caution, following proper safety procedures, as it may have some hazardous properties and potential health risks upon exposure.

InChI:InChI=1/C9H8N2O2/c1-12-8-5-3-2-4-7(8)9-11-10-6-13-9/h2-6H,1H3

Upstream product

• 7466-54-8 2-methoxybenzoylhydrazine 
• 122-51-0 orthoformic acid triethyl ester 
• 579-75-9 2-Methoxybenzoic acid 
• 2476-35-9 5-bromo-2-methoxybenzoic acid 
• 536-74-3 phenylacetylene 
• 100-42-5 styrene 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 1008-65-7 2-(1,3,4-oxadiazol-2-yl)-phenol 
• 74-88-4 methyl iodide 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 896740-87-7 C₁₉H₂₇N₃O₅ 
• 1414598-53-0 2-(2-methoxyphenyl)-5-(4-methylphenylthio)-1,3,4-oxadiazole 
• 1008-65-7 2-(1,3,4-oxadiazol-2-yl)-phenol 
• 240115-75-7 2-(1,3,4-oxadiazol-2-yl)phenyl benzoate 
• 1446317-80-1 2-(2-methoxyphenyl)-5-(1-trifluoromethyl-2,3,5,6-tetrafluorophenyl)-1,3,4-oxadiazole 
• 1446317-71-0 2-(2-methoxyphenyl)-5-(pentafluorophenyl)-1,3,4-oxadiazole 
• 1398814-74-8 (2-methoxy)-2-phenyl-1,3,4-oxadiazolyldiphenylphosphine 

Relevant articles and documents

Spectral-Luminescent Properties of 2-Aryl-1,3,4-oxadiazoles

Refluxing equimolar amounts of acylhydrazides with triethyl orthoformate in o-xylene yielded 2-aryl-1,3,4-oxadiazoles luminescing with high quantum yields in polar and nonpolar solvents (λm fl ax 299–349 nm, φ 0.20–0.62). The only exception was 2-(1,3,4-o

Iodine-Mediated Domino Oxidative Cyclization: One-Pot Synthesis of 1,3,4-Oxadiazoles via Oxidative Cleavage of C(sp2)-H or C(sp)-H Bond

An I2-promoted, metal-free domino protocol for one-pot synthesis of 1,3,4-oxadiazoles has been developed via oxidative cleavage of C(sp2)-H or C(sp)-H bonds, followed by cyclization and deacylation. In this reaction, the use of K2CO3 as a base is found to be an essential factor in the cyclization and the C-C bond cleavage. This procedure proceeded smoothly in moderate to high yields with good functional group compatibility.

Transition metal-free direct C-H bond thiolation of 1,3,4-oxadiazoles and related heteroarenes

A convenient transition metal-free procedure for the direct thiolation of 1,3,4-oxadiazole C-H bonds using diaryl disulfides has been developed. Other substrates including indole, benzothiazole, N-phenylbenzimidazole, and caffeine were also thiolated in this manner, providing the corresponding products in good to excellent yields. This journal is