429673-86-9Relevant academic research and scientific papers
Asymmetric synthesis of 3,4-anti- and 3,4-syn-substituted aminopyrrolidines via lithium amide conjugate addition
Davies, Stephen G.,Garner, A. Christopher,Goddard, Euan C.,Kruchinin, Dennis,Roberts, Paul M.,Smith, Andrew D.,Rodriguez-Solla, Humberto,Thomson, James E.,Toms, Steven M.
, p. 1961 - 1969 (2008/02/08)
The diastereoselective conjugate addition of homochiral lithium amides to methyl 4-(N-allyl-N-benzylamino)but-2-enoate has been used as the key step in a simple and efficient protocol for the preparation of 3,4-substituted aminopyrrolidines. This protocol provides a complementary and stereoselective route to both anti- and syn-3-amino-4-alkylpyrrolidines as well as anti- and syn-3-hydroxy-4-aminopyrrolidines, in high de and ee via β-amino enolate functionalisation. This methodology has been applied to the synthesis of anti-(3S,4S)- and syn-(3R,4S)-3-methoxy-4-(N-methylamino)pyrrolidine. The Royal Society of Chemistry.
Lithium amide conjugate addition for the asymmetric synthesis of 3-aminopyrrolidines
Davies, Stephen G.,Garner, A. Christopher,Goddard, Euan C.,Kruchinin, Dennis,Roberts, Paul M.,Rodriguez-Solla, Humberto,Smith, Andrew D.
, p. 2664 - 2666 (2008/09/20)
Conjugate addition of homochiral lithium amides to methyl 4-(N-benzyl-N-allylamino)but-2-enoate, chemoselective N-deprotection and concomitant cyclisation, followed by enolate functionalisation and deprotection allows access to syn- and anti-3,4-disubstituted aminopyrrolidines in > 98% d.e. and > 98% e.e. The Royal Society of Chemistry 2006.
Quinolinecarboxylic acids
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, (2008/06/13)
Novel quinolonecarboxylic acids of the formula: STR1 wherein R1 is C1 -C4 alkyl, R2 and R3 each is identically or differently hydrogen or C1 -C4 alkyl, R4 is cycloprop
