429679-57-2

Upstream product

• 100-39-0 benzyl bromide 
• 294637-61-9 1,5-anhydro-3-O-(4-bromobenzyl)-2-deoxy-6-O-triisopropylsilyl-D-arabino-hex-1-enitol 

Downstream Products

• 429679-59-4 4-pentenyl 2,4-di-O-benzyl-6-O-triisopropylsilyl-β-D-mannopyranoside 
• 429679-64-1 4-pentenyl 4-O-benzyl-3-O-(4-bromobenzyl)-6-O-triisopropylsilyl-β-D-mannopyranoside 
• 429679-56-1 4-pentenyl 2,4-di-O-benzyl-3-O-(4-bromobenzyl)-6-O-triisopropylsilyl-β-D-mannopyranoside 
• 429679-61-8 4-pentenyl 2-O-acetyl-3,4,6-tri-O-benzyl-α-D-mannopyranosyl-(1->3)-2,4-di-O-benzyl-β-D-mannospyranoside 
• 429679-60-7 4-pentenyl 2-O-acetyl-3,4,6-tri-O-benzyl-α-D-mannopyranosyl-(1->3)-2,4-di-O-benzyl-6-O-triisopropylsilyl-β-D-mannospyranoside 
• 429679-58-3 4-pentenyl 4-O-benzyl-3-O-(4-bromobenzyl)-6-O-triisopropylsilyl-β-D-glucopyranoside 

Relevant academic research and scientific papers

A linear synthesis of branched high-mannose oligosaccharides from the HIV-1 viral surface envelope glycoprotein gp120

Described is a linear solution-phase synthesis of the HIV-1 viral surface envelope glycoprotein gp120 high-mannose nonasaccharide pentyl glycoside. Envisioning the automated solid-phase assembly of complex carbohydrates, the synthesis of the nonasaccharide and the related tri- and hexamannosides demonstrates the facile assembly of highly branched structures in a stepwise fashion incorporating monosaccharide building blocks. A differentially protected core trisaccharide was prepared and further elongated in two high-yielding tri-mannosylations to furnish the triantennary structure. The tri-, hexa-, and nonamannoside n-pentyl glycosides obtained via the described synthesis are currently being used for detailed study of the carbohydrate protein interactions responsible for binding of the anti-HIV protein cyanovirin-N to the glycoprotein gp120. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.