4300-43-0

Basic information

• Product Name: N,N′-BIS-(3,4-DICHLOROPHENYL)UREA
• Synonyms: Urea,N,N’-bis(3,4-dichlorophenyl);Nsc 35217;Nsc 70259;Triclocarban Related CoMpound C
• CAS NO: 4300-43-0
• Molecular Formula: C₁₃H₈Cl₄N₂O
• Molecular Weight: 350.031
• Mol File: 4300-43-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 281-282 °C
• Boiling Point: 369.2°Cat760mmHg
• Flash Point: 177.1°C
• Appearance: /
• Density: 1.608g/cm³
• Vapor Pressure: 1.2E-05mmHg at 25°C
• Refractive Index: 1.705
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 12.16±0.70(Predicted)
• CAS DataBase Reference: N,N′-BIS-(3,4-DICHLOROPHENYL)UREA(CAS DataBase Reference)
• NIST Chemistry Reference: N,N′-BIS-(3,4-DICHLOROPHENYL)UREA(4300-43-0)
• EPA Substance Registry System: N,N′-BIS-(3,4-DICHLOROPHENYL)UREA(4300-43-0)

Safety Data

• Hazardous Substances Data: 4300-43-0(Hazardous Substances Data)

Usage

Uses

3,3'',4,4''-Tetrachlorocarbanilide is a chlorocarbanilide co-?contaminate in US aquatic environments.

InChI:InChI=1/C13H8Cl4N2O/c14-9-3-1-7(5-11(9)16)18-13(20)19-8-2-4-10(15)12(17)6-8/h1-6H,(H2,18,19,20)

Upstream product

• 102-36-3 3,4-dichlorophenylisocyanate 
• 95-76-1 m,p-dichloroaniline 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 
• 57-13-6 urea 
• 56-40-6 glycine 
• 107-97-1 sarcosine 

Downstream Products

• 103-71-9 phenyl isocyanate 
• 95-76-1 m,p-dichloroaniline 
• 1918-18-9 methyl N-(3,4-dichlorophenyl)carbamate 

Relevant articles and documents

QSAR and classification of murine and human soluble epoxide hydrolase inhibition by urea-like compounds

A data set of 348 urea-like compounds that inhibit the soluble epoxide hydrolase enzyme in mice and humans is examined. Compounds having IC50 values ranging from 0.06 to >500 μM (murine) and 0.10 to >500 μM (human) are categorized as active or

N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation

Compositions and methods for inhibiting translation initiation are provided. Compositions, methods and kits for treating (1) cellular proliferative disorders, (2) non-proliferative, degenerative disorders, (3) viral infections, and/or (4) disorders associated with viral infections, using N,N′-diarylureas and/or N,N′-diarylthiourea compounds are described.

A simple and efficient synthesis of diaryl ureas with reduction of the intermediate isocyanate by triethylamine

Thirty symmetrical diaryl urea derivatives were synthesised in moderate to excellent yields from arylamine and triphosgene with triethylamine as a reducing agent for the intermediate, isocyanate. It was significant that part of the products could be collected in almost quantitative yield without column chromatography. The procedure under mild reaction conditions was tolerant of a wide range of functional groups. The structures of the compounds were determined by NMR, MS and X-ray crystallographic analyses.