43007-89-2Relevant academic research and scientific papers
Design and synthesis of novel PPARα/γ/δ triple activators using a known PPARα/γ dual activator as structural template
Mogensen, John P.,Jeppesen, Lone,Bury, Paul S.,Pettersson, Ingrid,Fleckner, Jan,Nehlin, Jan,Frederiksen, Klaus S.,Albrektsen, Tatjana,Din, Nanni,Mortensen, Steen B.,Svensson, L. Anders,Wassermann, Karsten,Wulff, Erik M.,Ynddal, Lars,Sauerberg, Per
, p. 257 - 260 (2007/10/03)
Using a known dual PPARα/γ activator (5) as a structural template, SAR evaluations led to the identification of triple PPARα/γ/δ activators (18-20) with equal potency and efficacy on all three receptors. These compounds could become useful tools for studying the combined biological effects of PPARα/γ/δ activation.
